| Asian ethnicity in anonymous oocyte donors is associated with increased estradiol levels but comparable recipient pregnancy rates compared with Caucasians. | |
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MedLine Citation:
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PMID: 20056204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine if differences exist in ovarian response and pregnancy rates between Asian and Caucasian donors. DESIGN: Retrospective cohort study. SETTING: University-based clinic. PATIENT(S): Anonymous oocyte donors of self-reported Asian (n=63) or Caucasian (n=156) ethnicity who began ovarian stimulation between February 2000 and March 2008 and their matched recipients. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Recipient pregnancy rates and oocyte donor ovarian responsiveness. RESULT(S): Baseline characteristics were similar between Asian and Caucasian donors. Asian donors had peak serum estradiol levels that were 23% higher than their Caucasian counterparts (3715±220 vs. 3013±114 pg/mL). Adjusted estradiol levels per follicle measured and per oocyte retrieved were elevated in Asian donors (17% and 23% higher, respectively), and these differences were unchanged after adjusting for body mass index. No differences were noted in implantation rates (47.4% vs. 40.9%), clinical pregnancy rates (60.3% vs. 62.4%), or live-birth rates (55.5% vs. 59.9%) achieved using Asian vs. Caucasian oocyte donors. CONCLUSION(S): In contrast to autologous fresh in vitro fertilization cycles, Asian ethnicity is not associated with a lower pregnancy rate in recipient women using controlled hormone replacement when anonymous donor oocytes are used. Asian donors achieved statistically significantly higher serum estradiol levels during gonadotropin stimulation, suggesting an ethnic difference in steroid production and/or metabolism. |
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Authors:
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Heather G Huddleston; Mitchell P Rosen; Julie D Lamb; Aisha Modan; Marcelle I Cedars; Victor Y Fujimoto |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2010-01-13 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2059-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, California 94115-0916, USA. huddlestonh@obgyn.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anonymous Testing Asian Americans* / statistics & numerical data Estradiol / blood* European Continental Ancestry Group* / statistics & numerical data Female Humans Ovulation Induction / statistics & numerical data Pregnancy Pregnancy Rate / ethnology* Retrospective Studies Tissue Donors* / statistics & numerical data Up-Regulation Young Adult |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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