| Ashkenazi Jews and breast cancer: the consequences of linking ethnic identity to genetic disease. | |
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MedLine Citation:
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PMID: 17018815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We explored the advantages and disadvantages of using ethnic categories in genetic research. With the discovery that certain breast cancer gene mutations appeared to be more prevalent in Ashkenazi Jews, breast cancer researchers moved their focus from high-risk families to ethnicity. The concept of Ashkenazi Jews as genetically unique, a legacy of Tay-Sachs disease research and a particular reading of history, shaped this new approach even as methodological imprecision and new genetic and historical research challenged it. Our findings cast doubt on the accuracy and desirability of linking ethnic groups to genetic disease. Such linkages exaggerate genetic differences among ethnic groups and lead to unequal access to testing and therapy. |
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Authors:
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Sherry I Brandt-Rauf; Victoria H Raveis; Nathan F Drummond; Jill A Conte; Sheila M Rothman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-10-03 |
Journal Detail:
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Title: American journal of public health Volume: 96 ISSN: 1541-0048 ISO Abbreviation: Am J Public Health Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-25 Completed Date: 2006-11-06 Revised Date: 2010-09-16 |
Medline Journal Info:
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Nlm Unique ID: 1254074 Medline TA: Am J Public Health Country: United States |
Other Details:
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Languages: eng Pagination: 1979-88 Citation Subset: AIM; IM |
Affiliation:
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Center for the Study of Society and Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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ethnology*,
genetics* Female Founder Effect Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease / ethnology* Genetic Research* Genetic Testing Genetics, Population* Humans Interviews as Topic Jews / classification, genetics* Judaism Mutation Research Personnel Social Identification* Tay-Sachs Disease / ethnology, genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01 HG002517-01AG/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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