Document Detail

Aseptic meningitis associated with rofecoxib.
MedLine Citation:
PMID:  11911727     Owner:  NLM     Status:  MEDLINE    
Rofecoxib is a nonsteroidal anti-inflammatory drug that is reported to act by selectively inhibiting cyclooxygenase-2. A review and analysis of reports sent to the Spontaneous Reporting System of the Food and Drug Administration, Rockville, Md, suggest that aseptic meningitis is associated with rofecoxib use. To our knowledge, there have been no published reports of aseptic meningitis occurring in association with rofecoxib use to date. We report 5 serious cases of aseptic meningitis associated with rofecoxib use.
Renan A Bonnel; Maria L Villalba; Claudia B Karwoski; Julie Beitz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  162     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-25     Completed Date:  2002-04-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-5     Citation Subset:  AIM; IM    
Office of Postmarketing Drug Risk Assessment, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Ln, Room 15B-23, HFD-430, Rockville, MD 20857, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Arthritis, Rheumatoid / drug therapy
Carpal Tunnel Syndrome / drug therapy
Lactones / adverse effects*,  therapeutic use
Meningitis, Aseptic / chemically induced*,  diagnosis
Middle Aged
Neck Pain / drug therapy
Osteoarthritis / drug therapy
Pain, Postoperative / drug therapy
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Lactones; 0/Sulfones; 0/rofecoxib

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