Document Detail

Aseptic meningitis associated with cephalosporins in an infant with trisomy 21.
MedLine Citation:
PMID:  17641271     Owner:  NLM     Status:  MEDLINE    
The authors report a case of aseptic meningitis associated with cephalosporins in an infant. A 1-year-old boy with trisomy 21 received several antimicrobials including cefotaxime and ceftriaxone for bacterial meningitis caused by Haemophilus influenzae b. High fever continued for more than a month, and discontinuation of cefotaxime broke the fever and improved the findings of cerebrospinal fluid. Because third-generation cephalosporins are the first choice against bacterial meningitis for infants, recognition and diagnosis of this rare occurrence of drug-induced aseptic meningitis is important. It is treatable by withdrawal of the drug, and recurrence can be prevented.
Wako Nakajima; Akira Ishida; Maya Takahashi; Yoko Sato; Tomoo Ito; Goro Takada
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  22     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-20     Completed Date:  2007-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  780-2     Citation Subset:  IM    
Department of Pediatrics, Akita University School of Medicine, Akita, Japan.
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MeSH Terms
Anti-Bacterial Agents / adverse effects*
Body Temperature / drug effects
C-Reactive Protein / metabolism
Cephalosporins / adverse effects*
Down Syndrome / drug therapy,  microbiology,  pathology
Haemophilus influenzae / pathogenicity*
Meningitis, Aseptic / etiology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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