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Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs.
MedLine Citation:
PMID:  22149461     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Both oxidative stress and endotoxins mediated immunological reactions play a major role in the progression of alcoholic hepatic fibrosis. Ascorbic acid has been reported to reduce alcohol induced toxicity and ascorbic acid levels are reduced in alcoholics. Hence we investigated the hepatoprotective action of ascorbic acid in the reversal of alcohol induced hepatic fibrosis in male guinea pigs (n=36) and it was compared with animals absenting from alcohol treatment. In comparison with alcohol abstention group, there was a reduction in the activities of toxicity markers and levels of lipid and protein peroxidation products, expression of a-SMA, caspase-3 activity and mRNA levels of CYP2E1, TGF-β(1), TNF-α, and α(1)(I) collagen in liver of ascorbic acid supplemented group. The ascorbic acid content in liver was significantly reduced in alcohol treated guinea pigs. But it was reversed to normal level in ascorbic acid supplemented group. The anti-fibrotic action of ascorbic acid in the rapid regression of alcoholic liver fibrosis may be attributed to decrease in the oxidative stress, hepatic stellate cells activation, cytotoxicity and mRNA expression of fibrotic genes CYP2E1, TGF-β1, TNF-α and α(1) (I) collagen in hepatic tissues.
Authors:
P A Abhilash; R Harikrishnan; M Indira
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-8
Journal Detail:
Title:  Free radical research     Volume:  -     ISSN:  1029-2470     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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