| Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. | |
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MedLine Citation:
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PMID: 17412579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects. OBJECTIVE: Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB). METHODS: Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9alpha, 11beta-prostagladin (PG) F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period. Results: The ascorbic acid diet significantly reduced (p < 0.05) the maximum fall in post-exercise FEV1 (-6.4 +/- 2.4%) compared to usual (-14.3 +/- 1.6%) and placebo diet (-12.9 +/- 2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9alpha, 11beta-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. CONCLUSION: Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects. |
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Authors:
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Sandra L Tecklenburg; Timothy D Mickleborough; Alyce D Fly; Yeon Bai; Joel M Stager |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-04-05 |
Journal Detail:
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Title: Respiratory medicine Volume: 101 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-11-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1770-8 Citation Subset: IM |
Affiliation:
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Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E. 7th St, HPER 112, Bloomington, IN 47401, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Asthmatic Agents / administration & dosage* Ascorbic Acid / administration & dosage* Asthma / prevention & control* Asthma, Exercise-Induced / diet therapy Bronchoconstriction / drug effects* Cross-Over Studies Dietary Supplements* Double-Blind Method Exercise Test / adverse effects Female Humans Male Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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