Document Detail

Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma.
MedLine Citation:
PMID:  17412579     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous research has shown that diet can modify the bronchoconstrictor response to exercise in asthmatic subjects.
OBJECTIVE: Determine the effect of ascorbic acid supplementation on pulmonary function and several urinary markers of airway inflammation in asthmatic subjects with exercise-induced bronchoconstriction (EIB).
METHODS: Eight asthmatic subjects with documented EIB participated in a randomized, placebo controlled double-blind crossover trial. Subjects entered the study on their usual diet and were placed on either 2 weeks of ascorbic acid supplementation (1500 mg/day) or placebo, followed by a 1-week washout period, before crossing over to the alternative diet. Pre- and post-exercise pulmonary function, asthma symptom scores, fraction of exhaled nitric oxide (FENO), and urinary leukotriene (LT) C4-E4 and 9alpha, 11beta-prostagladin (PG) F2] were assessed at the beginning of the trial (usual diet) and at the end of each treatment period.
RESULTS: The ascorbic acid diet significantly reduced (p < 0.05) the maximum fall in post-exercise FEV1 (-6.4 +/- 2.4%) compared to usual (-14.3 +/- 1.6%) and placebo diet (-12.9 +/- 2.4%). Asthma symptoms scores significantly improved (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet. Post-exercise FENO, LTC4-E4 and 9alpha, 11beta-PGF2 concentration was significantly lower (p<0.05) on the ascorbic acid diet compared to the placebo and usual diet.
CONCLUSION: Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects.
Sandra L Tecklenburg; Timothy D Mickleborough; Alyce D Fly; Yeon Bai; Joel M Stager
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-04-05
Journal Detail:
Title:  Respiratory medicine     Volume:  101     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-11-19     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1770-8     Citation Subset:  IM    
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MeSH Terms
Anti-Asthmatic Agents / administration & dosage*
Ascorbic Acid / administration & dosage*
Asthma / prevention & control*
Asthma, Exercise-Induced / diet therapy
Bronchoconstriction / drug effects*
Cross-Over Studies
Dietary Supplements*
Double-Blind Method
Exercise Test / adverse effects
Respiratory Function Tests
Reg. No./Substance:
0/Anti-Asthmatic Agents; PQ6CK8PD0R/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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