| Ascorbic acid reduces tropoelastin levels in culture medium of chick skin fibroblasts. | |
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MedLine Citation:
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PMID: 8869038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascorbic acid reduced tropoelastin levels in the culture medium of embryonic chick skin fibroblasts to one-third or one-fourth of their original value in a dose- and exposure time-dependent manner under conditions in which collagen synthesis was stimulated 1.8-fold. The steady-state level of elastin mRNA remained essentially constant, whereas the collagen mRNA content increased in proportion to the increase in collagen synthesis with ascorbic acid treatment. These results suggest that the reduction of tropoelastin levels is not controlled by the elastin mRNA level but, rather, is related to the posttranslational modification of the tropoelastin molecule. |
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Authors:
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A Hayashi; S Tajima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of dermatological science Volume: 11 ISSN: 0923-1811 ISO Abbreviation: J. Dermatol. Sci. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1997-01-03 Completed Date: 1997-01-03 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9011485 Medline TA: J Dermatol Sci Country: IRELAND |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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genetics Animals Ascorbic Acid / pharmacology* Cells, Cultured Chick Embryo Collagen / genetics, metabolism Culture Media / metabolism* Fibroblasts / metabolism RNA, Messenger / metabolism Skin / cytology, metabolism* Tropoelastin / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Culture Media; 0/RNA, Messenger; 0/Tropoelastin; 50-81-7/Ascorbic Acid; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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