Document Detail

Ascorbic acid reduces tropoelastin levels in culture medium of chick skin fibroblasts.
MedLine Citation:
PMID:  8869038     Owner:  NLM     Status:  MEDLINE    
Ascorbic acid reduced tropoelastin levels in the culture medium of embryonic chick skin fibroblasts to one-third or one-fourth of their original value in a dose- and exposure time-dependent manner under conditions in which collagen synthesis was stimulated 1.8-fold. The steady-state level of elastin mRNA remained essentially constant, whereas the collagen mRNA content increased in proportion to the increase in collagen synthesis with ascorbic acid treatment. These results suggest that the reduction of tropoelastin levels is not controlled by the elastin mRNA level but, rather, is related to the posttranslational modification of the tropoelastin molecule.
A Hayashi; S Tajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dermatological science     Volume:  11     ISSN:  0923-1811     ISO Abbreviation:  J. Dermatol. Sci.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-01-03     Completed Date:  1997-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9011485     Medline TA:  J Dermatol Sci     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Actins / genetics
Ascorbic Acid / pharmacology*
Cells, Cultured
Chick Embryo
Collagen / genetics,  metabolism
Culture Media / metabolism*
Fibroblasts / metabolism
RNA, Messenger / metabolism
Skin / cytology,  metabolism*
Tropoelastin / genetics,  metabolism*
Reg. No./Substance:
0/Actins; 0/Culture Media; 0/RNA, Messenger; 0/Tropoelastin; 50-81-7/Ascorbic Acid; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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