Document Detail

Ascorbic acid prevents vascular dysfunction induced by oral glucose load in healthy subjects.
MedLine Citation:
PMID:  22153532     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To examine the effects of oral glucose load on forearm circulatory regulation before and after ascorbic acid administration in healthy subjects.
DESIGN: Microcirculation study with laser Doppler was performed at the hand in basal conditions, after ischemia and after acetylcholine and nitroprusside; strain gauge plethysmography was performed at basal and after ischemia. The tests were repeated in the same sequence 2 hour after oral administration of glucose (75g). The subjects were randomised for administration of ascorbic acid (1g bid) or placebo (sodium bicarbonate 1g bid) for 10days. After that, the tests were repeated before and after a new oral glucose load. Blood pressure and heart rate were monitored.
RESULTS: Macrocirculatory flux, pressure values and heart rate were unvaried throughout the study. The glucose load caused a reduction in the hyperemic peak flow with laser Doppler and plethysmography; it reduced flux recovery time and hyperemic curve area after ischemia; acetylcholine elicited a minor increase in flux with laser Doppler. The response to nitroprusside was unvaried after glucose load as compared to basal conditions. Treatment with ascorbic acid prevented the decrease in hyperemia after glucose, detected with laser Doppler and plethysmography. Ascorbic acid prevented the decreased response to acetylcholine after glucose, the response to nitroprusside was unaffected by ascorbic acid. Results after placebo were unvaried.
CONCLUSIONS: Oral glucose load impairs endothelium dependent dilation and hyperaemia at microcirculation, probably via oxidative stress; ascorbic acid can prevent it.
Sergio De Marchi; Manlio Prior; Anna Rigoni; Sara Zecchetto; Fanny Rulfo; Enrico Arosio
Publication Detail:
Type:  Journal Article     Date:  2011-08-27
Journal Detail:
Title:  European journal of internal medicine     Volume:  23     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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