| Ascorbic acid inhibits the migration of Walker 256 carcinosarcoma cells. | |
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MedLine Citation:
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PMID: 17965972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The results of several experimental studies have shown that ascorbic acid inhibits tumor growth and metastasis. Ascorbic acid is an antioxidant that acts as a scavenger for a wide range of reactive oxygen species (ROS). Both tumour metastasis and cell migration have been correlated with the intracellular ROS level, so it was postulated that the inhibitory effect of ascorbic acid derivatives on cell motility may be caused by scavenging of ROS. Time-lapse analyses of Walker 256 carcinosarcoma cell migration showed that both the speed of movement and the cell displacement were inhibited by ascorbic acid applied in concentrations ranging from 10 to 250 microM. This effect correlated with a reduction in the intracellular ROS level in WC 256 cells, suggesting that ROS scavenging may be a mechanism responsible for the inhibition of WC 256 cell migration. However, another potent antioxidant, N-acetyl-L-cysteine, also efficiently decreased the intracellular ROS level in WC 256 cells, but did not affect the migration of the investigated cells. These results demonstrate that intact, unmodified ascorbic acid applied in physiologically relevant and non-toxic concentrations exerts an inhibitory effect on the migration of WC 256 carcinosarcoma cells, and that this may be one of the factors responsible for the anti-metastatic activity of vitamin C. However, our data does not support the hypothesis that the scavenging of intracellular ROS is the main mechanism in the inhibition of cancer cell migration by ascorbic acid. |
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Authors:
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Ewa Wybieralska; Monika Koza; Jolanta Sroka; Jarosław Czyz; Zbigniew Madeja |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-29 |
Journal Detail:
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Title: Cellular & molecular biology letters Volume: 13 ISSN: 1689-1392 ISO Abbreviation: Cell. Mol. Biol. Lett. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-12-31 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607427 Medline TA: Cell Mol Biol Lett Country: Poland |
Other Details:
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Languages: eng Pagination: 103-11 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378, Kraków, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / physiology Ascorbic Acid / physiology* Carcinoma 256, Walker / metabolism*, pathology* Cell Line, Tumor Cell Migration Inhibition* Cell Movement / physiology* Rats Reactive Oxygen Species / metabolism Sarcoma / metabolism*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Reactive Oxygen Species; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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