Document Detail


Ascorbic acid inhibits ROS production, NF-kappa B activation and prevents ethanol-induced growth retardation and microencephaly.
MedLine Citation:
PMID:  15721175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we established an embryo model to study the effects of ethanol on fetal development. When embryos of Xenopus laevis (the African clawed frog) were exposed to ethanol, the resultant tadpoles had significantly reduced brain sizes (microencephaly) and retarded growth rates. These effects, similar to those observed in human fetal alcohol syndrome (FAS), were dose- and time-dependent. We further showed that the antioxidant ascorbic acid (vitamin C) could inhibit the ethanol-induced reactive oxygen species (ROS) production and NF-kappaB activation and protect the ethanol-treated embryos against microencephaly and growth retardation. These results suggest the involvement of NF-kappaB and oxidative stress in ethanol-mediated developmental defects, and the potential use of ascorbic acid as a new and effective protective agent for FAS.
Authors:
Ying Peng; K H H Kwok; Pai-Hao Yang; Samuel S M Ng; Jie Liu; O G Wong; Ming-Liang He; Hsiang-Fu Kung; Marie C M Lin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-25
Journal Detail:
Title:  Neuropharmacology     Volume:  48     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  426-34     Citation Subset:  IM    
Affiliation:
Department of Neurology, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 510120. ypeng@hkucc.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascorbic Acid / pharmacology*,  therapeutic use
Ethanol / antagonists & inhibitors,  toxicity*
Fetal Growth Retardation / chemically induced,  prevention & control*
Microcephaly / chemically induced,  prevention & control*
NF-kappa B / antagonists & inhibitors*,  metabolism
Reactive Oxygen Species / antagonists & inhibitors*,  metabolism
Xenopus laevis
Chemical
Reg. No./Substance:
0/NF-kappa B; 0/Reactive Oxygen Species; 50-81-7/Ascorbic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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