| Ascorbic acid induces apoptosis in adult T-cell leukemia. | |
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MedLine Citation:
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PMID: 17352246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adult T-cell leukemia (ATL) is an acute malignancy of activated T-cells caused by the human T-cell lymphotrophic virus type-1 (HTLV-1). MATERIALS AND METHODS: The effects of non-cytotoxic concentrations of ascorbic acid (AA) were evaluated against HTLV-1 positive and negative cells. The effect of AA on apoptosis and proliferation was evaluated by cell cycle analysis. The role of p53, p21 Bax and Bcl-2a on cell cycle modulation and apoptosis was also assessed. The anti-proliferative effects were tested by determining the changes in the expression of transforming growth factors (TGF-alpha, TGF-beta1 and TGF-beta2). RESULTS: Ascorbic acid was found to reduce the proliferation of cells and induce apoptosis by the modulation of p53, p21, Bcl-2 and Bax. CONCLUSION: The results of this study show the anti-proliferative effects of AA against leukemic cells. |
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Authors:
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Steve Harakeh; Mona Diab-Assaf; Jihane C Khalife; Khalil A Abu-el-Ardat; Elias Baydoun; Aleksandra Niedzwiecki; Marwan E El-Sabban; Mathias Rath |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 27 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-03-13 Completed Date: 2007-03-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 289-98 Citation Subset: IM |
Affiliation:
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Department of Biology, American University of Beirut, Beirut, Lebanon. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Ascorbic Acid / pharmacology* Cell Cycle / drug effects Cell Growth Processes / drug effects Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis Enzyme-Linked Immunosorbent Assay Flow Cytometry HTLV-I Infections / complications, drug therapy*, pathology Human T-lymphotropic virus 1* Humans Jurkat Cells Leukemia-Lymphoma, Adult T-Cell / drug therapy*, metabolism, pathology, virology Proto-Oncogene Proteins c-bcl-2 / biosynthesis Transforming Growth Factors / biosynthesis Tumor Suppressor Protein p53 / biosynthesis bcl-2-Associated X Protein / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/BAX protein, human; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Proto-Oncogene Proteins c-bcl-2; 0/TP53 protein, human; 0/Tumor Suppressor Protein p53; 0/bcl-2-Associated X Protein; 50-81-7/Ascorbic Acid; 76057-06-2/Transforming Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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