Document Detail


Ascorbic acid induces apoptosis in adult T-cell leukemia.
MedLine Citation:
PMID:  17352246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Adult T-cell leukemia (ATL) is an acute malignancy of activated T-cells caused by the human T-cell lymphotrophic virus type-1 (HTLV-1). MATERIALS AND METHODS: The effects of non-cytotoxic concentrations of ascorbic acid (AA) were evaluated against HTLV-1 positive and negative cells. The effect of AA on apoptosis and proliferation was evaluated by cell cycle analysis. The role of p53, p21 Bax and Bcl-2a on cell cycle modulation and apoptosis was also assessed. The anti-proliferative effects were tested by determining the changes in the expression of transforming growth factors (TGF-alpha, TGF-beta1 and TGF-beta2). RESULTS: Ascorbic acid was found to reduce the proliferation of cells and induce apoptosis by the modulation of p53, p21, Bcl-2 and Bax. CONCLUSION: The results of this study show the anti-proliferative effects of AA against leukemic cells.
Authors:
Steve Harakeh; Mona Diab-Assaf; Jihane C Khalife; Khalil A Abu-el-Ardat; Elias Baydoun; Aleksandra Niedzwiecki; Marwan E El-Sabban; Mathias Rath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  27     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-03-13     Completed Date:  2007-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  289-98     Citation Subset:  IM    
Affiliation:
Department of Biology, American University of Beirut, Beirut, Lebanon.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*
Ascorbic Acid / pharmacology*
Cell Cycle / drug effects
Cell Growth Processes / drug effects
Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
HTLV-I Infections / complications,  drug therapy*,  pathology
Human T-lymphotropic virus 1*
Humans
Jurkat Cells
Leukemia-Lymphoma, Adult T-Cell / drug therapy*,  metabolism,  pathology,  virology
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
Transforming Growth Factors / biosynthesis
Tumor Suppressor Protein p53 / biosynthesis
bcl-2-Associated X Protein / biosynthesis
Chemical
Reg. No./Substance:
0/BAX protein, human; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Proto-Oncogene Proteins c-bcl-2; 0/TP53 protein, human; 0/Tumor Suppressor Protein p53; 0/bcl-2-Associated X Protein; 50-81-7/Ascorbic Acid; 76057-06-2/Transforming Growth Factors

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