Document Detail

Ascorbic acid improves impaired venous and arterial endothelium-dependent dilation in smokers.
MedLine Citation:
PMID:  15780194     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the acute effects of ascorbic acid on vasodilation of veins and arteries in vivo. METHODS: Twenty-six healthy non-smokers and 23 healthy moderate smokers were recruited in this study. The dorsal hand vein compliance technique and flow-mediated dilation were used. Dose-response curves to bradykinin and sodium nitroprusside were constructed to test the endothelium-dependent and -independent relaxation before and after acute infusion of ascorbic acid. RESULTS: Smokers had an impaired venodilation with bradykinin compared with non-smokers (68.3%+/-13.2% vs 93.7%+/-20.1%, respectively; P<0.05). Ascorbic acid administration in the dorsal hand vein significantly increased the venodilation with bradykinin in smokers (68.3%+/-13.2% vs 89.5%+/-6.3% before and after infusion, respectively; P<0.05) but not in non-smokers (93.7%+/-20.1% vs 86.4%+/-12.4% before and after infusion, respectively). Similarly, the arterial response in smokers had an impaired endothelium-dependent dilation compared with that in non-smokers (8.8%+/-2.7% vs 15.2%+/-2.3%, respectively; P<0.05) and ascorbic acid restored this response in smokers (8.8%+/-2.7% vs 18.7%+/-6.5% before and after infusion, respectively; P<0.05), but no difference was seen in non-smokers (15.2%+/-2.3% vs 14.0%+/-4.4% before and after infusion, respectively). The endothelium-independent dilation did not differ in both the groups studied. No important hemodynamic change was detected using the Portapress device. CONCLUSION: Smokers had impaired endothelium-dependent vasodilation responsiveness in both arterial and venous systems. Ascorbic acid restores this responsiveness in smokers.
Marcio Goncalves de Sousa; Juan Carlos Yugar-Toledo; Marcelo Rubira; Silvia Elaine Ferreira-Melo; Rodrigo Plentz; Deise Barbieri; Fernanda Consolim-Colombo; Maria Claudia Irigoyen; Heitor Moreno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  26     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-22     Completed Date:  2005-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  447-52     Citation Subset:  IM    
Cardiovascular Pharmacology and Cardiology, Clinical Hospital of Campinas and Faculty of Medical Sciences, State University of Campinas, 13081-970, Campinas, Sao Paulo, Brazil.
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MeSH Terms
Ascorbic Acid / pharmacology*
Brachial Artery / physiopathology
Bradykinin / pharmacology
Dose-Response Relationship, Drug
Endothelium, Vascular / drug effects*
Hand / blood supply
Nitroprusside / pharmacology
Smoking / physiopathology*
Vasodilation / drug effects*
Veins / physiopathology
Reg. No./Substance:
15078-28-1/Nitroprusside; 50-81-7/Ascorbic Acid; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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