Document Detail

Ascorbic acid effect on intestinal iron absorption in different types of anaemias.
MedLine Citation:
PMID:  816695     Owner:  NLM     Status:  MEDLINE    
The study deals with investigations on anaemia due to iron or protein calorie deficiency and that associating acute glomerulonephritis, nephrosis and schistosoma haematobium. The rate of intestinal iron absorption using an oral dose of ferrous sulphate equivalent to 4 mg clemental iron/kg body weight was studied. The supplementing action of ascorbic acid in iron absorption in these cases was also investigated. The rate of intestinal iron absorption was enhanced in pure iron deficiency anaemia, acute glomerulonephritis and schistosoma haematobium, retarded in kwashiorkor, marasmus and nephrosis. Ascorbic acid markedly promoted iron absorption in normal subjects but slightly in pure iron deficiency anaemia. It improved iron absorption in acute glomerulonephritis and schistosoma haematobium but not in kwashiorkor, marasmus and nephrotic cases. It is concluded that ascorbic acid supplementation is of certain beneficial effect in alleviating the state of anaemia when intestinal iron absorption is not impaired. Also, it may prove to be of value to be given along with protein rehabilitation in anaemias associating protein deficiency.
M F El-Hawary; F A El-Shobaki; T Kholeif; R Sakr; E M El-Bassousy; K Abdel-Khalek; A Khashaba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Gazette of the Egyptian Paediatric Association     Volume:  23     ISSN:  1110-6638     ISO Abbreviation:  Gaz Egypt Paediatr Assoc     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7509401     Medline TA:  Gaz Egypt Paediatr Assoc     Country:  EGYPT    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
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MeSH Terms
Anemia / metabolism*
Anemia, Hypochromic / metabolism
Ascorbic Acid / pharmacology*
Child, Preschool
Glomerulonephritis / metabolism
Intestinal Absorption / drug effects*
Iron / metabolism*
Protein-Energy Malnutrition / metabolism
Schistosomiasis / metabolism
Reg. No./Substance:
50-81-7/Ascorbic Acid; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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