Document Detail

Ascorbic acid and cortisol metabolism in hypovitaminosis C guineapigs.
MedLine Citation:
PMID:  7129799     Owner:  NLM     Status:  MEDLINE    
The relationship between the metabolic changes in tissue ascorbic acid (AA) and the release of 11-hydroxy corticosteroids (cortisol) into the blood of male and female guineapigs fed on vitamin C-deficient diet, has been investigated. The animals received the diet for 30 and 36 days (males and females respectively) during which tissue AA and Corticol concentrations were analysed at six-day intervals. Bodyweight and adrenal weights were also recorded. When guineapigs are deprived of vitamin C in their diet, tissue cortisol and ascorbic acid concentrations undergo concurrent metabolic changes. There is a close association between the metabolic changes in adrenal cortisol secretion and ascorbic acid release into the plasma as shown by the regression and correlation values. Adrenal ascorbic acid concentration falls as cortisol secretion into the plasma increases. These results indicate that adrenal ascorbic acid operates a modulating role over the production of adrenal steroids during stress in guineapigs.
A Odumosu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  52     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  176-85     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / metabolism*,  pathology
Ascorbic Acid / blood,  metabolism*
Ascorbic Acid Deficiency / metabolism*
Body Weight
Guinea Pigs / metabolism*
Hydrocortisone / metabolism*
Leukocytes / metabolism
Liver / metabolism*
Sex Factors
Reg. No./Substance:
50-23-7/Hydrocortisone; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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