Document Detail

Ascorbic acid and cortisol metabolism in hypovitaminosis C guineapigs.
MedLine Citation:
PMID:  7129799     Owner:  NLM     Status:  MEDLINE    
The relationship between the metabolic changes in tissue ascorbic acid (AA) and the release of 11-hydroxy corticosteroids (cortisol) into the blood of male and female guineapigs fed on vitamin C-deficient diet, has been investigated. The animals received the diet for 30 and 36 days (males and females respectively) during which tissue AA and Corticol concentrations were analysed at six-day intervals. Bodyweight and adrenal weights were also recorded. When guineapigs are deprived of vitamin C in their diet, tissue cortisol and ascorbic acid concentrations undergo concurrent metabolic changes. There is a close association between the metabolic changes in adrenal cortisol secretion and ascorbic acid release into the plasma as shown by the regression and correlation values. Adrenal ascorbic acid concentration falls as cortisol secretion into the plasma increases. These results indicate that adrenal ascorbic acid operates a modulating role over the production of adrenal steroids during stress in guineapigs.
A Odumosu
Related Documents :
7784399 - Biosynthesis of ascorbic acid in germinating rapeseed cultivars.
11185659 - Decreased turnovers of glutathione and ascorbic acid in watanabe heritable hyperlipidem...
12600959 - Certification of standard reference material 970, ascorbic acid in serum, and analysis ...
2987149 - Stopped flow esr study of the action of carbohydrates on ascorbic acid oxidation in aqu...
6117609 - A postabsorption effect of l-ascorbic acid on copper metabolism in chicks.
24932929 - Expanding the comprehensive national neonatal screening programme in the united arab em...
1477109 - Fast atom bombardment, electron ionization and chemical ionization mass spectrometry of...
868439 - Compartmentation of the amino acid pool in saccharomycopsis lipolytica.
19299029 - Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-se...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  52     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  176-85     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Glands / metabolism*,  pathology
Ascorbic Acid / blood,  metabolism*
Ascorbic Acid Deficiency / metabolism*
Body Weight
Guinea Pigs / metabolism*
Hydrocortisone / metabolism*
Leukocytes / metabolism
Liver / metabolism*
Sex Factors
Reg. No./Substance:
50-23-7/Hydrocortisone; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Studies on the possible mechanism of hydrazine action on ascorbic acid-metabolising enzymes.
Next Document:  The vitamin status of Viennese school children aged 11-12 years.