Document Detail


Ascorbic acid, PGE2 and acetylcholine interaction: the effect on isolated smooth muscle.
MedLine Citation:
PMID:  3466510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of L-ascorbic acid (AA) on the isolated rat stomach fundus and guinea pig ileum was studied. AA induced contractions of these organs and potentiated the effect of ACh and PGE2. The contractile effect of AA was potentiated by eserine and inhibited by atropine. Dose-response relations suggest a stimulatory effect of AA on the muscarinic receptor.
Authors:
E Poćwiardowska-Ciara; Z Korolkiewicz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Polonica     Volume:  37     ISSN:  0044-6033     ISO Abbreviation:  Acta Physiol Pol     Publication Date:    1986 Jan-Feb
Date Detail:
Created Date:  1987-01-07     Completed Date:  1987-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985166R     Medline TA:  Acta Physiol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology*
Animals
Ascorbic Acid / pharmacology*
Dinoprostone
Drug Interactions
Female
Gastric Fundus / drug effects
Guinea Pigs
Ileum / drug effects
Male
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects*
Prostaglandins E / pharmacology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Prostaglandins E; 363-24-6/Dinoprostone; 50-81-7/Ascorbic Acid; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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