Document Detail


Ascorbate polyphosphate is a bioavailable vitamin C source in juvenile rainbow trout: tissue saturation and compartmentalization model.
MedLine Citation:
PMID:  7500184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the bioavailability of ascorbic acid ester, ascorbate polyphosphate, to juvenile rainbow trout (Oncorhynchus mykiss). Fish were fed molar equivalents of 0, 20, 40, 80, 160, 320 and 1280 mg ascorbic acid/kg diet in the form of ascorbate polyphosphate. During the 18 wk of the experiment, when body weight increase averaged 3.5-fold, we did not observe any deficiency symptoms in any group. Liver and kidney ascorbate concentrations differed significantly among groups after wk 9. The ascorbic acid concentrations in liver were significantly different in fish fed for 9 wk an equivalent of 0, 40 and 160 mg ascorbic acid/kg as ascorbate polyphosphate, values were 22.7 +/- 3.4, 93.7 +/- 17.0 and 368.0 +/- 60.8 nmol ascorbic acid/g. The ascorbic acid concentrations in kidney were significantly different in fish fed for 18 wk an equivalent of 0,20 and 40 mg ascorbic acid/kg as ascorbic polyphosphate (23.9 +/- 4.0, 72.1 +/- 13.6 and 254.4 +/- 22.7 nmol ascorbic acid/g, respectively). After wk 18, fish from groups fed 0, 20, 320 and 1280 mg ascorbic polyphosphate/kg were intraperitoneally injected with 25 mg/ascorbic acid/kg body wt. We observed differences in the profiles of tissue ascorbate concentration during the 96 h following the injection between groups with high and low tissue ascorbate concentration, i.e., fish fed 320 and 0 ascorbic acid/kg, respectively. We conclude that ascorbic acid metabolism in rainbow trout after intraperitoneal injection followed the three-compartmental model, with the intraperitoneal cavity as the first compartment, blood as the second, and tissues as the third.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M Matusiewicz; K Dabrowski; L Volker; K Matusiewicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  125     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3055-61     Citation Subset:  IM    
Affiliation:
School of Natural Resources, Ohio State University, Columbus 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Ascorbic Acid / analogs & derivatives*,  analysis,  metabolism,  pharmacokinetics*
Biological Availability
Diet / standards
Dose-Response Relationship, Drug
Female
Food, Fortified
Kidney / chemistry,  metabolism*
Liver / chemistry,  metabolism*
Male
Models, Biological*
Oncorhynchus mykiss / metabolism*
Organophosphorus Compounds / analysis,  metabolism,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Organophosphorus Compounds; 0/ascorbate-2-polyphosphate; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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