Document Detail


Ascertainment bias cannot entirely account for human microsatellites being longer than their chimpanzee homologues.
MedLine Citation:
PMID:  9700197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large majority of human microsatellite markers are longer than their homologues in chimpanzees, suggesting that more expansion mutations have occurred in the lineage leading to humans. However, such a length difference has also been explained as arising from the selection of unusually long microsatellites as genetic markers. In order to resolve this controversy and to establish the true source of the observed length differences, we have now conducted the necessary reciprocal study. We have compared the lengths of size-selected markers cloned from chimpanzees between this species and humans. We find that of 19 markers which were informative and polymorphic in both species, 13 are longer in humans. This result is incompatible with ascertainment bias being the sole explanation for the inter-specific length differences. We estimate that dinucleotide repeat microsatellites are an average of 3.2 repeat units longer in humans than in chimpanzees, implying a mutational bias in favour of microsatellite expansions and a higher average genome-wide microsatellite mutation rate in the human lineage.
Authors:
G Cooper; D C Rubinsztein; W Amos
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human molecular genetics     Volume:  7     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-16     Completed Date:  1998-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1425-9     Citation Subset:  IM    
Affiliation:
University of Cambridge, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK. gc215@cus.cam.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
DNA Primers / genetics
Dinucleotide Repeats
Evolution, Molecular
Humans
Microsatellite Repeats*
Pan troglodytes / genetics*
Polymorphism, Genetic
Species Specificity
Chemical
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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