| Ascending and transverse aortic arch repair: the impact of glomerular filtration rate on mortality. | |
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MedLine Citation:
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PMID: 18376199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies have described the importance of renal glomerular filtration rate (GFR) as a determinant of perioperative mortality in patients with aneurysms that involve the thoracoabdominal and abdominal aorta. We studied the impact of GFR on mortality following repair of ascending and arch aneurysms. METHODS: Between February 1991 and August 2006, we performed 994 repairs of the ascending and transverse aortic arch. Nine hundred twenty patients had evaluable data for this study. Sixty-two percent were men (566/920); mean age was 65 years (range 17-89). We estimated the GFR using the Cockcroft-Gault equation. Mean preoperative serum creatinine was 1.2 +/- 0.9 mg/dl, mean GFR was 77 +/- 37 mL/min. Renal function data were arrayed in quartiles for univariate analysis and kept continuous for multivariable analyses. Multivariable analyses assessed demographics, extent of disease, acuity of presentation, and renal function measured by both creatinine and GFR. RESULTS: Overall 30-day mortality was 10.8% (99/920). In univariate analyses, GFR (P < 0.0001), serum creatinine (P < 0.0003), coronary artery disease (P > 0.03), acute dissection (P < 0.03), emergency presentation (P < 0.002), age (P < 0.009), pump time (P < 0.0001), cross-clamp time, (P < 0.03) and circulatory arrest time (P < 0.003) were associated with increased mortality. By multivariable analyses, only GFR (P < 0.0001), pump time (P < 0.0001), emergency status (P < 0.002) were significant independent risk factors for mortality. CONCLUSIONS: Preoperative renal function as defined by GFR was the most significant predictor of mortality during repairs of the ascending and transverse aortic arch. The use of GFR provides better preoperative risk stratification during these repairs than creatinine alone. |
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Authors:
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Anthony L Estrera; Charles C Miller; Jaswanth Madisetty; Sebastian Bourgeois; Ali Azizzadeh; Martin A Villa; Hazim J Safi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Annals of surgery Volume: 247 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: United States |
Other Details:
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Languages: eng Pagination: 524-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiothoracic and Vascular Surgery, The University of Texas at Houston Medical School, Memorial Hermann Heart and Vascular Institute, Houston, TX 77030, USA. anthony.l.estrera@uth.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Aneurysm, Dissecting / mortality Aorta, Thoracic / surgery* Aortic Aneurysm, Thoracic / mortality*, surgery* Coronary Disease / complications Creatinine / blood Female Glomerular Filtration Rate* Humans Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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5 P50 HL083794-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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