Document Detail

Ascending aortic blood pressure waveform may be related to the risk of coronary artery disease in women, but not in men.
MedLine Citation:
PMID:  15042115     Owner:  NLM     Status:  MEDLINE    
Recent studies have demonstrated that fractional pulse pressure and fractional diastolic pressure are related to the risk of coronary artery disease. However, the effect of the ascending aortic pressure waveform on the risk of coronary artery disease in men and women analyzed separately has not been reported. The objective of the study was to assess the relation between ascending aortic blood pressure waveform and the presence of coronary artery disease in men and in women. The study group consisted of 447 patients (302 men and 145 women; mean age: 57.6+/-9.8 years) with preserved left ventricular function who were undergoing first diagnostic coronary angiography. After multivariate stepwise adjustments, the odds ratio (OR) and confidence interval (CI) of having coronary artery disease in women was (OR are reported for standard deviation increase in each variable): pulse pressure OR 1.61 (95% CI 1.06-2.46); fractional systolic pressure OR 1.72 (95% CI 1.08-2.71); fractional diastolic pressure OR 0.58 (95% CI 0.37-0.92); fractional pulse pressure OR 1.72 (95% CI 1.08-2.71); and pulsatility index OR 1.74 (95% CI 1.09-2.78). None of the studied variables was independently related to the presence of coronary artery disease in men. In conclusion, fractional systolic and diastolic pressure, pulse pressure, fractional pulse pressure and the ratio of pulse pressure to diastolic pressure may be independently related to the risk of coronary artery disease in women, but not in men.
P Jankowski; K Kawecka-Jaszcz; D Czarnecka; L Bryniarski
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  18     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-23     Completed Date:  2006-07-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
Department of Cardiology, Collegium Medicum Jagiellonian University, ul. Kopernika 17, 31-501 Kraków, Poland.
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MeSH Terms
Aorta* / physiopathology
Blood Pressure*
Coronary Angiography
Coronary Artery Disease / physiopathology*,  radiography
Middle Aged
Multivariate Analysis
Myocardial Contraction
Odds Ratio
Poland / epidemiology
Pulsatile Flow*
Research Design
Risk Factors
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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