Document Detail


Asbestos fibers contributing to the induction of human malignant mesothelioma.
MedLine Citation:
PMID:  12562635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: 1. Asbestos fibers were present in almost all of the lung and mesothelial tissues from the mesothelioma cases. 2. The most common types of asbestos fibers in lung were either an admixture of chrysotile with amphiboles, amphibole alone, and occasionally chrysotile alone. In mesothelial tissues, most asbestos fibers were chrysotile. 3. In lung, amosite fibers were greatest in number followed by chrysotile, crocidolite, tremolite/actinolite, and anthophyllite. In mesothelial tissues, chrysotile fibers were 30.3 times more common than amphiboles. 4. In some mesothelioma cases, the only asbestos fibers detected in either lung or mesothelial tissue were chrysotile fibers. 5. The average number of asbestos fibers in both lung and mesothelial tissues was two orders of magnitude greater than the number found in the general population. 6. The majority of asbestos fibers in lung and mesothelial tissues were shorter than 5 micro m in length.
CONCLUSIONS: 1) Fiber analysis of both lung and mesothelial tissues must be done to determine the types of asbestos fibers associated with the induction of human malignant mesothelioma; 2) short, thin asbestos fibers should be included in the list of fiber types contributing to the induction of human malignant mesothelioma; 3) RESULTS support the induction of human malignant mesothelioma by chrysotile.
Authors:
Yasunosuke Suzuki; Steven R Yuen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  982     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-03     Completed Date:  2003-04-02     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asbestos / adverse effects*
Body Burden
Female
Humans
Lung / drug effects,  pathology
Lung Neoplasms / chemically induced*,  epidemiology
Male
Mesothelioma / chemically induced*,  epidemiology
Occupational Diseases / epidemiology*
Occupational Exposure
Peritoneal Neoplasms / chemically induced,  epidemiology
Pleural Neoplasms / chemically induced,  epidemiology
Chemical
Reg. No./Substance:
1332-21-4/Asbestos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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