Document Detail


Asbestos exposure and antineutrophil cytoplasmic Antibody (ANCA) positivity.
MedLine Citation:
PMID:  15562639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors used indirect immunofluorescence to examine the association of antineutrophil cytoplasmic antibodies (ANCAs) with exposure to asbestos among 61 asbestos-exposed patients (mean exposure = 24.6 yr) and 39 nonexposed controls. ANCA positivity was detected significantly more frequently (p = 0.034) in the asbestos-exposed group (21.3%) than in the control group (5.1%). ANCA-associated diseases did not occur more frequently among subjects exposed previously to asbestos than among unexposed controls. These findings confirmed that exposure to asbestos is another occupational factor, as is silica exposure, that is associated with ANCA positivity. The influence of asbestos appears stronger than that of silica because ANCA positivity was found among subjects who had histories of exposure to asbestos but who did not exhibit typical radiographic signs of asbestosis on their chest x-rays. Additional stimuli may be necessary to induce systemic vasculitis in asbestos-exposed persons.
Authors:
Daniela Pelclová; Jirina Bartůnková; Zdenka Fenclová; Jindriska Lebedová; Marie Hladíková; Hana Benáková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental health     Volume:  58     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-11-25     Completed Date:  2004-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  662-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Occupational Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic. daniela.pelclova@LF1.cuni.cz
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antineutrophil Cytoplasmic / blood*
Asbestos*
Asbestosis / immunology
Female
Fluorescent Antibody Technique, Indirect
Humans
Male
Middle Aged
Occupational Exposure*
Chemical
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 1332-21-4/Asbestos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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