| Arylesterase and paraoxonase activity of paraoxonase (PON1) affected by ischemia in the plasma of patients with arterial occlusion of the lower limbs. | |
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MedLine Citation:
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PMID: 18976644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of the study was to evaluate the effect of different degrees of chronic ischemia of the lower limbs on PON1 activity in plasma, in relation to different substrates. DESIGN AND METHODS: The studied group consisted of patients with chronic arterial occlusion of the lower limbs due to atherosclerosis. The paraoxonase and arylesterase activities of PON1 were measured according to the Karen Gan method. RESULTS: PON1 arylesterase activity was affected by ischemia of the lower limbs depending on its degree. In the group with critical ischemia decreased PON1 activity was observed in comparison with that in the moderate ischemia group and the control group (50.05+/-21.40 U/mL and 82.59+/-29.27 U/mL, 85.30+/-35.05 U/mL, respectively). CONCLUSIONS: The results revealed a reverse relationship between PON1 activity and the progress of atherosclerosis to the ischemic level. The present study demonstrates, for the first time, that the arylesterase activity of PON1 is affected by critical ischemia of the lower limbs. |
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Authors:
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Magdalena Kasprzak; Maria Iskra; Wacław Majewski; Tomasz Wielkoszyński |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-17 |
Journal Detail:
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Title: Clinical biochemistry Volume: 42 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 50-6 Citation Subset: IM |
Affiliation:
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Department of General Chemistry, Chemistry and Clinical Biochemistry, Poznań University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland. magdarut@ump.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arterial Occlusive Diseases / blood* Aryldialkylphosphatase / blood, metabolism* Atherosclerosis / blood Carboxylic Ester Hydrolases / blood, metabolism* Humans Ischemia / blood*, physiopathology* Lower Extremity / blood supply* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.2/arylesterase; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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