Document Detail

Arylalkylamine N-acetyltransferase gene expression in retina and pineal gland of rats under various photoperiods.
MedLine Citation:
PMID:  15147969     Owner:  NLM     Status:  MEDLINE    
The present study examines how the circadian oscillators in the retina and the suprachiasmatic nucleus (SCN) respond to changes in photoperiod. Arylalkylamine N-acetyltransferase (aa-nat) gene expression studied by quantitative RT-PCR revealed that in adult Sprague-Dawley rats kept under different light-dark (LD) cycles for two weeks the temporal pattern of AA-NAT mRNA expression was identical in retina and pineal gland. In both tissues, the time span between the onset of darkness and the nocturnal rise in AA-NAT mRNA expression was 3 h under LD 20:4, 6 h under LD 12:12, and 15 h under LD 4:20. As aa-nat expression in the pineal gland is regulated by the circadian oscillator in SCN, the results suggest that the photoperiodic differences accompanying the seasons of the year are imprinted in more than one oscillator and that this may accentuate the important message regarding 'time of year.'
Lydia Engel; Lutz Vollrath; Rainer Spessert
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  318     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-18     Completed Date:  2004-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  983-6     Citation Subset:  IM    
Department of Anatomy, Johannes Gutenberg University, 55099 Mainz, Germany.
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MeSH Terms
Arylamine N-Acetyltransferase / biosynthesis*,  genetics
Circadian Rhythm / physiology
Gene Expression
Pineal Gland / enzymology*
RNA, Messenger / biosynthesis,  genetics
Rats, Sprague-Dawley
Retina / enzymology*
Reg. No./Substance:
0/RNA, Messenger; EC N-Acetyltransferase

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