| Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry. | |
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MedLine Citation:
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PMID: 7649917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolonged exposure to O2 causes diffuse alveolar damage and surfactant dysfunction that contribute to the pathophysiology of hyperoxic lung injury. We hypothesized that exogenous surfactant would improve lung function during O2 exposure in primates. Sixteen healthy male baboons (10-15 kg) were anesthetized and mechanically ventilated for 96 h. The animals received either 100% O2 (n = 6) or 100% O2 plus aerosolized artificial surfactant (Exosurf; n = 5). A third group of animals (n = 5) was ventilated with an inspired fraction of O2 of 0.21 to control for the effects of sedation and mechanical ventilation. Hemodynamic parameters were obtained every 12 h, and ventilation-perfusion distribution (VA/Q) was measured daily using a multiple inert-gas elimination technique. Positive end-expiratory pressure was kept at 2.5 cmH2O and was intermittently raised to 10 cmH2O for 30 min to obtain additional measurements of VA/Q. After the experiments, lungs were obtained for biochemical and histological assessment of injury. O2 exposures altered hemodynamics, progressively worsened VA/Q, altered lung phospholipid composition, and produced severe lung edema. Artificial surfactant therapy significantly increased disaturated phosphatidylcholine in lavage fluid and improved intrapulmonary shunt, arterial PO2, and lung edema. Surfactant also enhanced the shunt-reducing effect of positive end-expiratory pressure. We conclude that an aerosolized protein-free surfactant decreased the progression of pulmonary O2 toxicity in baboons. |
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Authors:
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Y C Huang; A C Sane; S G Simonson; T A Fawcett; R E Moon; P J Fracica; M G Menache; C A Piantadosi; S L Young |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 78 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-09-27 Completed Date: 1995-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1816-22 Citation Subset: IM; S |
Affiliation:
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Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Combinations Enzyme-Linked Immunosorbent Assay Fatty Alcohols / administration & dosage, metabolism, therapeutic use* Hemodynamics / drug effects, physiology Lung Diseases / drug therapy*, metabolism, physiopathology Male Oxygen / blood, toxicity* Papio Phospholipids / metabolism Phosphorylcholine* Polyethylene Glycols / administration & dosage, metabolism, therapeutic use* Positive-Pressure Respiration Proteolipids / metabolism Pulmonary Edema / drug therapy, physiopathology Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants / administration & dosage, metabolism, therapeutic use* Respiratory Mechanics / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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P01-HL-31992/HL/NHLBI NIH HHS; T32-HL-07528/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Fatty Alcohols; 0/Phospholipids; 0/Polyethylene Glycols; 0/Proteolipids; 0/Pulmonary Surfactant-Associated Proteins; 0/Pulmonary Surfactants; 107-73-3/Phosphorylcholine; 7782-44-7/Oxygen; 99732-49-7/Exosurf |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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