Document Detail


Artificial surfactant administration in an animal model of near drowning.
MedLine Citation:
PMID:  7497035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the use of exogenous surfactant in a rabbit fresh-water near-drowning model. METHODS: In a randomized, placebo-controlled experiment, 21 rabbits were anesthetized, paralyzed, and subjected to near drowning with 6 mL/kg of distilled water. Vital signs, arterial blood gases, and pulmonary compliance were measured at predetermined intervals. The animals were randomized into two groups: a normal O2 group that had their pO2 levels adjusted to 75-150 torr using supplemental O2 as needed, and a high O2 group ventilated with an FIO2 = 100%. Ventilator settings were further adjusted to normalize pH and pCO2 levels prior to instillation of distilled water. The two groups were further divided and 15 minutes after simulated near drowning, the animals were either treated with surfactant (5 mL/kg instilled endotracheally) or not treated. Data were analyzed by repeated-measures analysis of variance. RESULTS: Near drowning had no significant effect on heart rate or blood pressure. Acidosis was not changed by surfactant; hypoxia was worsened by surfactant: 158 +/- 54 torr before and 66 +/- 19 torr after administration (p < 0.01). Compliance did not change as a result of surfactant administration. Only the animals (n = 3) in the normal O2 plus surfactant group died during the 90-minute post-near-drowning period of the study. CONCLUSIONS: Surfactant administration (5 mL/kg) in this animal model of freshwater near drowning offers no benefit over simple ventilation. Assessment of the merit of smaller volumes of surfactant should be investigated because administration of this solution may represent a second pulmonary insult, given current volume recommendations.
Authors:
A L Anker; T Santora; W Spivey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine     Volume:  2     ISSN:  1069-6563     ISO Abbreviation:  Acad Emerg Med     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9418450     Medline TA:  Acad Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-10     Citation Subset:  IM    
Affiliation:
Department of Emergency Medicine, Medical College of Pennsylvania, Philadelphia, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blood Gas Analysis
Disease Models, Animal
Hemodynamics / drug effects
Lung Compliance / drug effects*
Near Drowning / mortality,  therapy*
Pulmonary Surfactants / administration & dosage,  adverse effects,  therapeutic use*
Rabbits
Random Allocation
Survival Rate
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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