Document Detail

Artificial rearing alters the response of rats to natural and drug-mediated rewards.
MedLine Citation:
PMID:  16617460     Owner:  NLM     Status:  MEDLINE    
Artificial rearing (AR) of infant rats permits precise control over key features of the early environment without maternal influence. The present study examined the behavioral response of AR rats towards natural and drug-mediated rewards, as well as their exploratory and affective behaviors. Adolescent AR rats showed increased preference for sucrose consumption relative to chow and demonstrated greater activity in the open field and in the elevated plus-maze compared to maternally reared (MR) rats. With respect to measures of emotionality, AR rats showed enhanced avoidance of the open arms of the plus-maze, indicating increased anxiety, but they did not differ from MR rats in exploring the center of the open field. Adult AR rats displayed a stronger conditioned response to morphine in a place preference test. These findings support the potential of the AR model to contribute to understanding the role of early experience in the development of behavioral motivation.
Anna M Lomanowska; Shadna A Rana; Dawn McCutcheon; Linda A Parker; Patricia E Wainwright
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  48     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-10-17     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-14     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley Periodicals, Inc.
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MeSH Terms
Affect / drug effects*
Behavior, Animal / drug effects
Brain / growth & development
Conditioning (Psychology)
Food Preferences
Morphine / pharmacology*
Narcotics / pharmacology*
Rats, Sprague-Dawley
Social Environment*
Reg. No./Substance:
0/Narcotics; 57-50-1/Sucrose; 76I7G6D29C/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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