| Artificial human tissues from cord and cord blood stem cells for multi-organ regenerative medicine: viable alternatives to animal in vitro toxicology. | |
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MedLine Citation:
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PMID: 20507188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New medicinal products and procedures must meet very strict safety criteria before being applied for use in humans. The laboratory procedures involved require the use of large numbers of animals each year. Furthermore, such investigations do not always give an accurate translation to the human setting. Here, we propose a viable alternative to animal testing, which uses novel technology featuring human cord and cord blood stem cells. With over 130 million children born each year, cord and cord blood remains the most widely available alternative to the use of animals or cadaveric human tissues for in vitro toxicology. |
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Authors:
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Marcin Jurga; Nico Forraz; Colin P McGuckin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alternatives to laboratory animals : ATLA Volume: 38 ISSN: 0261-1929 ISO Abbreviation: Altern Lab Anim Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110074 Medline TA: Altern Lab Anim Country: England |
Other Details:
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Languages: eng Pagination: 183-92 Citation Subset: IM |
Copyright Information:
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2010 FRAME. |
Affiliation:
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Parc Technologique de Lyon-Saint Priest, Woodstock Batiment Cedre 1, 97 Allee Alexandre Borodine, 69800 Saint Priest, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Testing Alternatives
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standards* Animals Artificial Organs* Ectoderm / cytology, physiology Endoderm / cytology, physiology Fetal Blood / cytology, immunology, physiology* Humans Immune Tolerance Infant, Newborn Mesoderm / cytology, physiology Regeneration / physiology* Stem Cells / cytology, immunology, physiology* Umbilical Cord / cytology, immunology, physiology* |
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