Document Detail

Artificial feeding synchronizes behavioral, hormonal, metabolic and neural parameters in mother-deprived neonatal rabbit pups.
MedLine Citation:
PMID:  22098455     Owner:  NLM     Status:  MEDLINE    
Nursing in the rabbit is under circadian control, and pups have a daily anticipatory behavioral arousal synchronized to this unique event, but it is not known which signal is the main entraining cue. In the present study, we hypothesized that food is the main entraining signal. Using mother-deprived pups, we tested the effects of artificial feeding on the synchronization of locomotor behavior, plasma glucose, corticosterone, c-Fos (FOS) and PERIOD1 (PER1) rhythms in suprachiasmatic, supraoptic, paraventricular and tuberomammillary nuclei. At postnatal day 1, an intragastric tube was placed by gastrostomy. The next day and for the rest of the experiment, pups were fed with a milk formula through the cannula at either 02:00 h or 10:00 h [feeding time = zeitgeber time (ZT)0]. At postnatal days 5-7, pups exhibited behavioral arousal, with a significant increase in locomotor behavior 60 min before feeding. Glucose levels increased after feeding, peaking at ZT4-ZT12 and then declining. Corticosterone levels were highest around the time of feeding, and then decreased to trough concentrations at ZT12-ZT16, increasing again in anticipation of the next feeding bout. In the brain, the suprachiasmatic nucleus had a rhythm of FOS and PER1 that was not significantly affected by the feeding schedule. Conversely, the supraoptic, paraventricular and tuberomammillary nuclei had rhythms of both FOS and PER1 induced by the time of scheduled feeding. We conclude that the nursing rabbit pup is a natural model of food entrainment, as food, in this case milk formula, is a strong synchronizing signal for behavioral, hormonal, metabolic and neural parameters.
Elvira Morgado; Claudia Juárez; Angel I Melo; Belisario Domínguez; Michael N Lehman; Carolina Escobar; Enrique Meza; Mario Caba
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-18
Journal Detail:
Title:  The European journal of neuroscience     Volume:  34     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-04-04     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1807-16     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Ver., México CIRA, CINVESTAV-UAT, Tlaxcala, Tlax., México.
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MeSH Terms
Animals, Newborn / physiology*
Behavior, Animal / physiology*
Blood Glucose / metabolism
Circadian Rhythm / physiology*
Corticosterone / blood
Feeding Behavior / physiology*
Hypothalamus / anatomy & histology,  physiology
Lactation / physiology*
Maternal Deprivation*
Motor Activity / physiology
Period Circadian Proteins / metabolism
Proto-Oncogene Proteins c-fos / metabolism
Grant Support
R01 TW006636-05/TW/FIC NIH HHS; R01TW006636/TW/FIC NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Period Circadian Proteins; 0/Proto-Oncogene Proteins c-fos; 50-22-6/Corticosterone

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