| Artificial blood - coming soon or never reaching clinical maturity? | |
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MedLine Citation:
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PMID: 20234994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Formerly developed resuscitation fluids solely imitated the main function of the blood -oxygen transport. A research driven by the army requested an oxygen carrier that does not need cross typing and cooled storage. Artificial oxygen carriers (AOC) use either the molecular oxygen bondage to hemoglobin: HBOC- "hemoglobin based oxygen carriers" or the physical dissolution of oxygen in the blood plasma compartment by hyperbaric pressure in perfluorocarbon emulsions (PFC). Decades of preclinical and clinical research did pass but the results were disappointing- in Russia, a not well designed PFC is available locally and the only approved HBOC in South Africa is not being used much. Other products, just prior to filing for FDA approval, did not achieve convincing study results and research and production was stopped. Some trials have been stopped by the FDA for safety reasons, half of trials with the primary endpoint reduction of allogeneic transfusion requirement were unsuccessful or offset by an increased blood requirement later. However, some ventures currently are trying to use the knowledge gained so far and are investigating third and fourth generation products of artificial blood components. These imitate the cellular structure of red cells as micells, nanocapsules, (ABC- artificial blood cells) or gas bubbles (microbubbles), admixture of volume substitutes such as starches, gelatin or albumin or use hyperbaric oxygenation [38]. Artificial platelets are in clinical phase IIa, recombinant albumin in phase III. In this article, a short overview about the current situation on artificial blood products is given. The critical point for the break through for artificial blood products did not come yet but could be ahead- |
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Authors:
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M Sch?ler; T Frietsch; C Jambor; R Knels |
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Publication Detail:
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Type: English Abstract; Journal Article; Review Date: 2010-03-16 |
Journal Detail:
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Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-17 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
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Languages: ger Pagination: 575-81 Citation Subset: IM |
Copyright Information:
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Copyright Georg Thieme Verlag KG Stuttgart . New York |
Affiliation:
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Klinik f?r An?sthesiologie und Operative Intensivmedizin, Medizinische Fakult?t Mannheim der Universit?t Heidelberg. |
Vernacular Title:
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Gibt es eine Zukunft f?r k?nstliche Blutersatzstoffe? |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Substitutes* Blood Transfusion / trends* Germany Humans Resuscitation / trends* |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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