| Artificial barrier repair in wounds by semi-occlusive foils reduced wound contraction and enhanced cell migration and reepithelization in mouse skin. | |
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MedLine Citation:
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PMID: 16297210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The repair of the permeability barrier to prevent the entry of harmful substances into the body is a goal in wound healing. Semi-occlusive foils, which provide an artificial barrier, are commonly used for the treatment of wounds. We examined the effects of foils on wound contraction, cell migration, and reepithelization. Full-thickness skin wounds in mice were covered with occlusive latex foils or semi-occlusive water vapor-permeable hydrocolloid foils for either the entire, the first half, or the second half of the wound-healing period. We found that application of foils for the entire healing period initially reduced wound healing during the first week of treatment, whereas healing was enhanced during the second week. Foils were found to reduce wound contraction, but enhanced reepithelization during the second week of wound healing because of increased proliferation and migration of keratinocytes. These effects were also noted when the hydrocolloid foils were applied for the second part of the healing period, only. The fully occlusive latex foil led to irritation of the skin, whereas less irritation occurred under semi-occlusive conditions. In summary, we found that artificial barrier repair with semi-occlusive foils in wounds reduced wound contraction and enhanced cell migration and reepithelization without irritation. |
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Authors:
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Michael Schunck; Claudia Neumann; Ehrhardt Proksch |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 125 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-21 Completed Date: 2006-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1063-71 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Kiel, Kiel, Germany. MSchunck@dermatology.uni-kiel.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bandages, Hydrocolloid* Cell Movement* Cell Proliferation Epithelium / chemistry, physiology* Mice Occlusive Dressings* Permeability Phosphorylation Regeneration STAT4 Transcription Factor / analysis, metabolism Skin / injuries* Wound Healing* |
| Chemical | |
Reg. No./Substance:
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0/STAT4 Transcription Factor; 0/Stat4 protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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