| Artificial food colors and attention-deficit/hyperactivity symptoms: conclusions to dye for. | |
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MedLine Citation:
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PMID: 22864801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of artificial food colors (AFCs) on child behavior has been studied for more than 35 years, with accumulating evidence from imperfect studies. This article summarizes the history of this controversial topic and testimony to the 2011 Food and Drug Administration Food Advisory Committee convened to evaluate the current status of evidence regarding attention-deficit/hyperactivity disorder (ADHD). Features of ADHD relevant to understanding the AFC literature are explained: ADHD is a quantitative diagnosis, like hypertension, and some individuals near the threshold may be pushed over it by a small symptom increment. The chronicity and pervasiveness make caregiver ratings the most valid measure, albeit subjective. Flaws in many studies include nonstandardized diagnosis, questionable sample selection, imperfect blinding, and nonstandardized outcome measures. Recent data suggest a small but significant deleterious effect of AFCs on children's behavior that is not confined to those with diagnosable ADHD. AFCs appear to be more of a public health problem than an ADHD problem. AFCs are not a major cause of ADHD per se, but seem to affect children regardless of whether or not they have ADHD, and they may have an aggregated effect on classroom climate if most children in the class suffer a small behavioral decrement with additive or synergistic effects. Possible biological mechanisms with published evidence include the effects on nutrient levels, genetic vulnerability, and changes in electroencephalographic beta-band power. A table clarifying the Food and Drug Administration and international naming systems for AFCs, with cross-referencing, is provided. |
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Authors:
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L Eugene Arnold; Nicholas Lofthouse; Elizabeth Hurt |
Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Volume: 9 ISSN: 1878-7479 ISO Abbreviation: Neurotherapeutics Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-09-14 Completed Date: 2013-02-15 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101290381 Medline TA: Neurotherapeutics Country: United States |
Other Details:
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Languages: eng Pagination: 599-609 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, The Ohio State University, Columbus, OH 43210, USA. L.Arnold@osumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Attention Deficit Disorder with Hyperactivity
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chemically induced*,
diagnosis Food Coloring Agents / adverse effects*, classification, history History, 20th Century Humans United States United States Food and Drug Administration |
| Chemical | |
Reg. No./Substance:
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0/Food Coloring Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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