| Artifactual hypoglycemia associated with hematopoietic cytokines. | |
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MedLine Citation:
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PMID: 7544105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We observed apparent hypoglycemia in seven patients manifesting granulocytosis associated with hematopoietic cytokine treatment or with a leukemoid reaction. All seven patients had confounding preanalytic conditions of specimen transport delay and lack of antiglycolytic agents. Cytokine-stimulated leukocytes may cause artifactual hypoglycemia by consuming glucose in vitro, possibly leading to unnecessary diagnostic evaluation. The glucose depletion was faster in blood drawn from patients receiving granulocyte colony-stimulating factor (0.29 mmol/L/h) than in blood from a control group (0.17 mmol/L/h) or from a group with leukemia (0.23 mmol/L/h). Stabilization with sodium fluoride (60 mmol/L) slowed the glucose depletion in both the cytokine group (0.13 mmol/L/h) and the leukemic group (0.09 mmol/L/h), which were then statistically indistinguishable from the control rate (0.10 mmol/L/h). In blood obtained from patients being treated with hematopoietic cytokines or who have leukemoid reactions, an antiglycolytic agent should be used whenever separation of plasma might be delayed more than 1 hour. |
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Authors:
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J R Astles; W P Petros; W P Peters; F A Sedor |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 119 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-20 Completed Date: 1995-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 713-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts* Cytokines / adverse effects*, physiology* Data Collection Fluorides / pharmacology Granulocyte Colony-Stimulating Factor / adverse effects, therapeutic use Hematopoiesis* Humans Hypoglycemia / epidemiology, etiology*, prevention & control Incidence Leukemia / blood Leukocytosis / complications, epidemiology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Fluorides; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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