Document Detail

Artifactual hypoglycemia associated with hematopoietic cytokines.
MedLine Citation:
PMID:  7544105     Owner:  NLM     Status:  MEDLINE    
We observed apparent hypoglycemia in seven patients manifesting granulocytosis associated with hematopoietic cytokine treatment or with a leukemoid reaction. All seven patients had confounding preanalytic conditions of specimen transport delay and lack of antiglycolytic agents. Cytokine-stimulated leukocytes may cause artifactual hypoglycemia by consuming glucose in vitro, possibly leading to unnecessary diagnostic evaluation. The glucose depletion was faster in blood drawn from patients receiving granulocyte colony-stimulating factor (0.29 mmol/L/h) than in blood from a control group (0.17 mmol/L/h) or from a group with leukemia (0.23 mmol/L/h). Stabilization with sodium fluoride (60 mmol/L) slowed the glucose depletion in both the cytokine group (0.13 mmol/L/h) and the leukemic group (0.09 mmol/L/h), which were then statistically indistinguishable from the control rate (0.10 mmol/L/h). In blood obtained from patients being treated with hematopoietic cytokines or who have leukemoid reactions, an antiglycolytic agent should be used whenever separation of plasma might be delayed more than 1 hour.
J R Astles; W P Petros; W P Peters; F A Sedor
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  119     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-20     Completed Date:  1995-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  713-6     Citation Subset:  AIM; IM    
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Cytokines / adverse effects*,  physiology*
Data Collection
Fluorides / pharmacology
Granulocyte Colony-Stimulating Factor / adverse effects,  therapeutic use
Hypoglycemia / epidemiology,  etiology*,  prevention & control
Leukemia / blood
Leukocytosis / complications,  epidemiology
Middle Aged
Reg. No./Substance:
0/Cytokines; 0/Fluorides; 143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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