Document Detail

Artifacts in ultrasonic contrast agent studies.
MedLine Citation:
PMID:  8015042     Owner:  NLM     Status:  MEDLINE    
Intravenously injected ultrasonic contrast agents making use of encapsulated gas microbubbles have excellent clinical potential for both color and spectral Doppler studies. However, a number of artifacts are associated with sonographic contrast agent measurements. Three artifacts were identified: (1) color "blooming," (2) increased maximum Doppler shift, and (3) spectral "bubble noise." Experiments have been conducted with Albunex and Levovist. These agents were injected into rabbits and humans to allow the cause of the artifacts to be established. Color blooming occurs soon after the bolus injection and is seen as gray scale pixels changing to color display. This is caused by the increase in flow signal strength. The apparent increase in the maximum Doppler shift frequency is due to the limited dynamic range of the spectral display. Only signals above a certain threshold are visible. As the Doppler signal power is enhanced, the highest frequency visible also increases. Finally, very large excursions can sometimes be seen in the spectral display (bubble noise). These might be due to either the breakdown of microbubbles or individual very large bubbles. The color blooming and bubble noise artifacts are easily identifiable and will not influence diagnostic management. The increase in peak Doppler shifts is more troublesome as it prevents comparison of spectral parameters obtained before and after injection of contrast agent.
F Forsberg; J B Liu; P N Burns; D A Merton; B B Goldberg
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  13     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-07-22     Completed Date:  1994-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-65     Citation Subset:  IM    
Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania.
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MeSH Terms
Albumins / diagnostic use
Contrast Media*
Models, Structural
Polysaccharides / diagnostic use
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508
Comment In:
J Ultrasound Med. 1999 Jan;18(1):87-8   [PMID:  9952084 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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