| Articulating spacers for the treatment of infected total knee arthroplasty: effect of antibiotic combinations and concentrations. | |
| | |
MedLine Citation:
|
PMID: 23276347 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Performing 2-stage procedures using articulating antibiotic cement spacers to eradicate infection while providing pain relief and maintaining function has become common among many surgeons. Despite the efficacy of antibiotic cement spacers in the treatment of infected total knee arthroplasty, questions remain regarding the dosing of the antibiotic cement.The authors assessed their experience with different antibiotic regimens and concentrations for the eradication of infection. Sixty-nine infected total knee arthroplasties with an average follow up of 31 months (range, 6-70 months) treated with articulating antibiotic spacers were retrospectively reviewed. Treatment groups were divided according to spacer antibiotic agents used and the amount of antibiotics added to the cement. Low-dose spacers were defined as those incorporating less than 4 g of antibiotic per 40-g bag of cement, and high-dose spacers were defined as those incorporating 4 g or more of antibiotic per 40-g bag of cement. High- vs low-dose spacers using a single or multiple antibiotic agents were compared. The overall rate of infection eradication was 88%. Dose dependency was not detected for spacers that incorporated single or multiple antibiotic agents, and multiple-agent spacers produced comparable success rates despite more frequent use in patients with impaired immune function.Further study of optimal combinations and concentrations of antibiotic agents incorporated into these spacers is needed to help minimize treatment failures while maximizing treatment efficacy. |
| | |
Authors:
|
John F Nettrour; John A Polikandriotis; Thomas L Bernasek; Kenneth A Gustke; Steven T Lyons |
Related Documents
:
|
23507037 - Combined treatment with benznidazole and allopurinol in mice infected with a virulent t... 22993177 - Gardnerella vaginalis as a rare cause of prosthetic joint infection. 23487367 - Markers of intestinal inflammation, not bacterial burden, correlate with clinical outco... 23056737 - Analysis of viral load in children infected with human metapneumovirus. 6178717 - Effect of combined antibiotic therapy on fertility in brood bitches infected with bruce... 15990977 - A murine model of pulmonary basidiomycosis by schizophyllum commune. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Orthopedics Volume: 36 ISSN: 1938-2367 ISO Abbreviation: Orthopedics Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806107 Medline TA: Orthopedics Country: United States |
Other Details:
|
Languages: eng Pagination: e19-24 Citation Subset: IM |
Copyright Information:
|
Copyright 2013, SLACK Incorporated. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional data for the diagnosis of patellofemoral laxity obtained by MRI during quadriceps isometr...
Next Document: Validity and reliability of radiographic knee osteoarthritis measures by arthroplasty surgeons.