Document Detail


Articular involvement in SSc.
MedLine Citation:
PMID:  22467084     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Articular involvement is frequent in SSc. It contributes to disability and compromises patients' quality of life. Different aspects of articular involvement have been described, ranging from arthralgia and arthritis to joint contracture and tendon sheath involvement. Recent cohort studies examining clinical and radiographic aspects of SSc have clarified the frequency of articular involvement and identified subsets of SSc patients with a higher risk of developing joint involvement. They have also highlighted the potential contribution of inflammatory arthritis to early SSc. Some pilot studies have underlined the potential usefulness of new imaging tools, such as ultrasonography and MRI for a better evaluation of joint involvement in SSc. Current treatment strategies for SSc-related inflammatory joint disease have not been evaluated in randomized controlled trials and generally derive from RA. MTX associated with low-dose CSs is the standard care for arthritis. Other treatment strategies (LEF and i.e. biologics borrowed from RA) may bring new opportunities to treat SSc-related arthritis and even SSc per se. However, the first step will be to study and validate outcome criteria in this insufficiently studied field.
Authors:
Jérôme Avouac; Philip J Clements; Dinesh Khanna; Daniel E Furst; Yannick Allanore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-30
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  -     ISSN:  1462-0332     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA and University of Michigan Scleroderma Program, Ann Arbor, MI, USA.
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