| Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes. | |
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MedLine Citation:
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PMID: 22234664 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Osteoarthritis patients with diabetes who receive total knee arthroplasty are more vulnerable to complications, including aseptic loosening and need for revision surgery. To elucidate mechanisms related to arthroplasty failure in diabetes, we examined serum and synovial fluid markers as well as collagen crosslinks in bone and cartilage of 20 patients (10 with diabetes, 10 controls without) undergoing this procedure. Hemoglobin A1c, body mass index, bone alkaline phosphatase, leptin, osteocalcin, and pyridinium were analyzed along with tissue content of the crosslinks hydroxylysylpyridinoline, lysylpyridinoline, and pentosidine. Pentosidine levels in tissue specimens from diabetic subjects were higher than in control subjects. Osteocalcin levels negatively correlated with hydroxylysylpyridinoline levels in cartilage. Osteocalcin levels also negatively correlated with pentosidine levels in cartilage, but only in subjects with diabetes. This study suggests potential metabolic mechanisms for arthroplasty failure in patients with diabetes. |
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Authors:
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Trevor W Oren; Sergiu Botolin; Allison Williams; Allan Bucknell; Karen B King |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of rehabilitation research and development Volume: 48 ISSN: 1938-1352 ISO Abbreviation: J Rehabil Res Dev Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8410047 Medline TA: J Rehabil Res Dev Country: United States |
Other Details:
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Languages: eng Pagination: 1195-210 Citation Subset: IM |
Affiliation:
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Department of Orthopaedics, University of Colorado School of Medicine, Aurora, CO. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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