| Arthropathy, leucopenia and recurrent infection associated with a TcR gamma delta population. | |
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MedLine Citation:
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PMID: 7582708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report documents the presence of clonal gamma delta T-cell receptor (TcR) population in the blood of a patient who presented with an arthropathy of undetermined cause, leucopenia and splenomegaly. There was no evidence for lymphoid malignancy clinically or at post-mortem. The phenotype and genotype of the clonal T-cell population were not associated with the predominant TcR delta rearrangement found in peripheral blood gamma delta cells, but were similar to those found in gamma delta TcR cells infiltrating rheumatoid synovium. The data indicate the presence of a monoclonal population of gamma delta cells TcR cells which in the face of continued immunosuppression behaved benignly. The case may represent a cytomorphologically atypical example of the large granular lymphocytes, neutropenia and arthropathy syndrome/lymphoproliferative disease of granular lymphocytes and, although the patient's clinical features were not 'classical', rheumatoid arthritis (RA) may have been the underlying primary disorder. |
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Authors:
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E Hodges; C Quin; A M Farrell; S Christmas; H F Sewell; M Doherty; R J Powell; J L Smith |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of rheumatology Volume: 34 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-12-18 Completed Date: 1995-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 978-83 Citation Subset: AIM; IM |
Affiliation:
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Molecular Immunology Group, Southampton University Hospitals NHS Trust. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthralgia
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complications,
immunology* Aspergillosis / complications, immunology* Gene Rearrangement, T-Lymphocyte Humans Leukopenia / complications, immunology* Male Middle Aged Phenotype Receptors, Antigen, T-Cell, gamma-delta* / genetics Recurrence Splenomegaly / complications, immunology* T-Lymphocyte Subsets / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, T-Cell, gamma-delta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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