Document Detail

Artery regional properties and atherosclerosis susceptibility.
MedLine Citation:
PMID:  17084416     Owner:  NLM     Status:  MEDLINE    
White carneau (WC) pigeons develop spontaneous atherosclerosis in contrast to atherosclerosis-resistant show racer (SR) pigeons. In this study, cellular and extracellular components and smooth muscle cell (SMC) proliferation rates of specific aortic sites were assessed in both breeds of pigeons prior to lesion development. The atherosclerosis-susceptible site of the WC aorta was characterized by larger lumen diameter without accompanying increase in wall thickness, as well as by SMC hypocellularity, increased proteoglycan content and higher elastin content. For both breeds, cells derived from the lesion site had lower proliferation rates compared to proximal aortic control sites. WC cells had greater proliferation rates than SR cells (109% greater at the atherosclerosis-prone site and 133% greater at the control site). Fibroblast growth factor (FGF) increased the proliferation of WC lesion site cells compared to SR cells (79% vs. 35%); whereas, transforming growth factor beta (TGFbeta) reduced growth in SR but not in WC cells. Differences in hemodynamic properties, in cell-matrix, elastin, proteoglycan and proliferation rates of cells and responses to FGF and TGFbeta in cells of the atherosclerosis-prone area have been identified as potential contributors to the enhanced atherosclerosis potential of this site in WC pigeons.
William D Wagner; Feng Guo; Micheal P Jokinen
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Publication Detail:
Type:  Journal Article     Date:  2006-09-23
Journal Detail:
Title:  Life sciences     Volume:  80     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM    
Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA.
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MeSH Terms
Aorta / metabolism,  pathology*
Atherosclerosis / metabolism,  pathology*
Cell Count
Cell Proliferation / drug effects
Cells, Cultured
Disease Models, Animal
Disease Susceptibility
Elastin / metabolism
Fibroblast Growth Factors / pharmacology
Muscle, Smooth, Vascular / drug effects,  metabolism,  pathology
Proteoglycans / metabolism
Recombinant Proteins / pharmacology
Transforming Growth Factor beta / pharmacology
Reg. No./Substance:
0/Proteoglycans; 0/Recombinant Proteins; 0/Transforming Growth Factor beta; 62031-54-3/Fibroblast Growth Factors; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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