| Arteriovenous differences of hematological and coagulation parameters in patients with sepsis. | |
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MedLine Citation:
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PMID: 20885299 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In critically ill patients, either arterial or venous blood is usually available for sampling and measurement of basic coagulation parameters. The aim of this study was to examine whether in these patients the values of coagulation parameters differ significantly with respect to the source of the blood samples. In a group of 44 patients with severe sepsis, we compared the values of coagulation, thromboelastography and selected hematological parameters between the arterial and venous blood. In most of the investigated parameters (international normalized ratio, activated partial thromboplastin time, fibrinogen concentration, erythrocyte count, leukocyte and platelet count, hemoglobin level and thromboelastography parameters), we did not find significant differences (P > 0.1). However, we found a significantly lower antithrombin activity and a significantly higher D-dimer concentration in venous blood compared to arterial blood (P < 0.05). This could be associated with increased consumption of antithrombin and generation of D-dimer as a consequence of microthrombi formation in the capillaries. We therefore conclude that for the purpose of assessment of coagulation status in septic patients, arterial and venous blood cannot be treated as equivalent. |
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Authors:
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Miroslav Durila; Tomáš Kalinčík; Sergej Jurčenko; Martina Pelichovská; Ivana Hadačová; Karel Cvachovec |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 21 ISSN: 1473-5733 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 770-4 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, Second Faculty of Medicine, Institute for Postgraduate Medical Education, Charles University, Prague, Czech Republic. durila4@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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