Document Detail

Arteriovenous carboxyhemoglobin difference is not correlated to TNF-alpha, IL-6, PCT, CRP and leukocytes in critically ill patients.
MedLine Citation:
PMID:  15469858     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is still unclear as to whether the paradoxical arteriovenous carboxyhemoglobin (COHb) difference found in critical illness may represent a novel marker of the acute inflammatory response. We determined whether the arterial and central venous COHb concentration or their difference may be correlated to classical pro-inflammatory markers. METHODS: Arterial and matched central venous blood gases were obtained from non-smoking intensive care patients undergoing gastrointestinal surgery, and were correlated with plasma concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP) and leukocytes. RESULTS: No correlation was found between arteriovenous COHb difference and the investigated pro-inflammatory mediators. While arterial and central venous COHb concentrations were positively correlated to plasma concentrations of TNF-alpha (P< or =0.01), IL-6 (P<0.05) and PCT (P< or =0.01), they were neither interrelated with PCT nor with leukocytes. CONCLUSIONS: Arteriovenous COHb difference does not appear to be a marker of the acute inflammatory response. Future studies are needed to investigate whether arterial and central venous COHb concentrations by themselves may serve as indicators of systemic inflammation.
Dina Eletr; Alexander Reich; Henning D Stubbe; Michael Booke; Fritz Daudel; Michael Erren; Martin Westphal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  349     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-07     Completed Date:  2005-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany.
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MeSH Terms
Blood Gas Analysis
C-Reactive Protein / metabolism*
Calcitonin / metabolism*
Carboxyhemoglobin / metabolism*
Critical Illness*
Inflammation Mediators
Interleukin-6 / metabolism*
Leukocytes / metabolism*
Middle Aged
Protein Precursors / metabolism*
Tumor Necrosis Factor-alpha / metabolism*
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 0/Protein Precursors; 0/Tumor Necrosis Factor-alpha; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein; 9061-29-4/Carboxyhemoglobin

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