| Arteriovenous carboxyhemoglobin difference is not correlated to TNF-alpha, IL-6, PCT, CRP and leukocytes in critically ill patients. | |
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MedLine Citation:
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PMID: 15469858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is still unclear as to whether the paradoxical arteriovenous carboxyhemoglobin (COHb) difference found in critical illness may represent a novel marker of the acute inflammatory response. We determined whether the arterial and central venous COHb concentration or their difference may be correlated to classical pro-inflammatory markers. METHODS: Arterial and matched central venous blood gases were obtained from non-smoking intensive care patients undergoing gastrointestinal surgery, and were correlated with plasma concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP) and leukocytes. RESULTS: No correlation was found between arteriovenous COHb difference and the investigated pro-inflammatory mediators. While arterial and central venous COHb concentrations were positively correlated to plasma concentrations of TNF-alpha (P< or =0.01), IL-6 (P<0.05) and PCT (P< or =0.01), they were neither interrelated with PCT nor with leukocytes. CONCLUSIONS: Arteriovenous COHb difference does not appear to be a marker of the acute inflammatory response. Future studies are needed to investigate whether arterial and central venous COHb concentrations by themselves may serve as indicators of systemic inflammation. |
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Authors:
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Dina Eletr; Alexander Reich; Henning D Stubbe; Michael Booke; Fritz Daudel; Michael Erren; Martin Westphal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 349 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-07 Completed Date: 2005-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Gas Analysis C-Reactive Protein / metabolism* Calcitonin / metabolism* Carboxyhemoglobin / metabolism* Critical Illness* Female Humans Inflammation Mediators Interleukin-6 / metabolism* Leukocytes / metabolism* Male Middle Aged Protein Precursors / metabolism* Tumor Necrosis Factor-alpha / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Interleukin-6; 0/Protein Precursors; 0/Tumor Necrosis Factor-alpha; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein; 9061-29-4/Carboxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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