Document Detail


Arteriosclerotic events are less frequent in persons with chronic anemia: evidence from families with hereditary spherocytosis.
MedLine Citation:
PMID:  16628733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because anemic persons have lower cholesterol and whole blood viscosity than those who are not anemic, we hypothesized that subjects with hereditary spherocytosis who have not had the spleen removed should have fewer arteriosclerotic events than unaffected family members. We defined arteriosclerotic events as myocardial infarct, stroke, coronary artery surgery, and carotid artery surgery. We compared the rate of these events in affected-not splenectomized persons to the rate in unaffected family members. The relative risk of an arteriosclerotic event in hereditary spherocytosis patients with a spleen was one fifth that in unaffected family members. These data support the hypothesis that chronic anemia retards the development of arteriosclerosis. Spherocytosis is another example of an inherited condition that conveys an advantage in one system and a disadvantage in another.
Authors:
Robert F Schilling; Ronald E Gangnon; Myrna Traver
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  81     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-26     Completed Date:  2006-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-7     Citation Subset:  IM    
Copyright Information:
2006 Wiley-Liss, Inc.
Affiliation:
Department of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA. rfsmd@medicine.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Arteriosclerosis / complications,  epidemiology*
Female
Hemoglobins / analysis
Humans
Male
Middle Aged
Retrospective Studies
Risk
Spherocytosis, Hereditary / complications,  epidemiology*,  surgery
Splenectomy
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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