Document Detail

Arteriosclerosis due to homocyst (e) inemia. Failure to reproduce the model in weanling rabbits.
MedLine Citation:
PMID:  4447126     Owner:  NLM     Status:  MEDLINE    
Weanling rabbits were injected subcutaneously daily for 35 days with homocysteine thiolactone in an attempt to repeat the results of McCully and Ragsdale. We failed to produce sustained homocyst(e)inemia (or homocysteine thiolactonemia); indeed, transient homocyst(e)inemia could only be demonstrated with a much higher dose of the free base of homocysteine given intraperitoneally. Homocysteine thiolactonemia was observed up to 15 minutes, only after an intravenous injection of homocysteine thiolactone. Analysis of urine and various organs for free amino acids also failed to detect homocyst(e)ine or the thiolactone. Morphologically, we were unable to distinguish between the experimental and control animals.
S Donahue; J A Struman; G Gaull
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  77     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1974 Nov 
Date Detail:
Created Date:  1975-04-17     Completed Date:  1975-04-17     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-3     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acid Metabolism, Inborn Errors / blood,  complications*,  pathology
Arteries / pathology*
Arteriosclerosis / blood,  etiology*,  pathology
Brain / pathology
Disease Models, Animal*
Homocysteine / administration & dosage,  blood*
Injections, Intraperitoneal
Injections, Subcutaneous
Kidney / pathology
Lung / pathology
Myocardium / pathology
Reg. No./Substance:

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