| Arteriolar constriction in mild-to-moderate essential hypertension: an old concept requiring reconsideration? | |
| | |
MedLine Citation:
|
PMID: 9211176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate differences between in-vivo properties of a vascular bed in hypertensive patients and normotensive controls. DESIGN: Despite the controversy about the origin of essential hypertension and its accompanying vascular changes, it is generally assumed that the characteristic increase in peripheral resistance when hypertension progresses is caused by arteriolar constriction. Yet, there is little experimental evidence that this assumption generally holds in vivo. METHODS: A non-invasive technique was used for studying properties of the complete vascular bed of an upper arm segment under an occluding cuff in 23 previously untreated hypertensive patients and their matched normotensive controls. The method used the segment's electrical impedance to assess the volumes of extravascular fluid and of arterial and venous blood under varying arterial transmural pressures. RESULTS: Compared with that of matched normotensive controls, the compliance of the large arteries of the vascular bed was on average 50.9% lower (P < 0.001) in the hypertensive patients. The compliance of the complete arterial bed at the operating blood pressure level was also lower (40.0%, P < 0.01), but appeared to be significantly higher (45.9%, P < 0.05) at the normotensive blood pressure level. On the venous side, the patients had a higher blood volume (60.0%, P < 0.01) and an increased myogenic response (68.5%, P < 0.05). CONCLUSIONS: The increase in vascular resistance in the hypertensive patients is due primarily to changes in the large and small vessels of the arterial bed. We found no evidence for a generally increased arteriolar constriction. |
| | |
Authors:
|
J H Muntinga; J T van Leeuwen; M E Gels; W F Terpstra; A J Smit; K R Visser |
Related Documents
:
|
3040806 - Mechanism of increased alpha adrenergic vasoconstriction in human essential hypertension. 3868716 - Free and conjugated catecholamines in plasma and erythrocytes of normotensive and labil... 158966 - Echocardiographic dimensions in borderline and sustained hypertension. 7473516 - Mildly raised corticosterone excretion rates in patients with essential hypertension. 10212366 - Reactivity of blood pressure to mental arithmetic stress test, stress-test recovery tim... 2310026 - Peripheral vascular effects of halothane and isoflurane in humans with an artificial he... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of hypertension Volume: 15 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1997 Apr |
Date Detail:
|
Created Date: 1997-08-18 Completed Date: 1997-08-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 411-9 Citation Subset: IM |
Affiliation:
|
Department of Medical Physiology, University of Groningen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Arterioles / physiopathology* Compliance Female Humans Hypertension / physiopathology* Male Middle Aged Vasoconstriction* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autonomic control of ultradian and circadian rhythms of blood pressure, heart rate, and baroreflex s...
Next Document: Kinins and the events influenced by an angiotensin-converting enzyme inhibitor during neointima form...