Document Detail


Arteriolar vascular smooth muscle cells: mechanotransducers in a complex environment.
MedLine Citation:
PMID:  22677491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Contraction of small artery (diameters typically less than 250 μm) vascular smooth muscle cells (VSMCs) plays a critical role in local control of blood flow and arterial pressure through its affect on vascular caliber. Specifically, contraction of small arteries in response to increased intraluminal pressure is referred to as the myogenic response and represents an important role for mechanotransduction. Critical questions remain as to how changes in pressure are sensed by VSMCs and transduced across the cell membrane to tune the contractile state of the cell. Recent studies suggest a pivotal role for interactions between VSMCs and extracellular matrix (ECM) proteins. Thus, pressure-induced deformation of ECM proteins and their cell surface receptors (for example, integrins) may initiate contraction and cytoskeletal remodeling through modulation of ion channels, membrane depolarization, increased intracellular Ca(2+) and actomyosin crossbridge cycling. Importantly, it is argued that the contractile properties of small artery VSMCs reflect an intimate and integrated interaction with their extracellular environment and the three-dimensional structure of the vessel wall.
Authors:
Michael A Hill; Gerald A Meininger
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-06-05
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  44     ISSN:  1878-5875     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-11-29     Revised Date:  2014-11-06    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1505-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / cytology*
Cell Differentiation
Disease
Mechanotransduction, Cellular*
Muscle, Smooth, Vascular / cytology*,  pathology,  physiology,  physiopathology
Grant Support
ID/Acronym/Agency:
HL HL092241/HL/NHLBI NIH HHS; P01-HL095486/HL/NHLBI NIH HHS; R01 HL092241/HL/NHLBI NIH HHS

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