Document Detail


Arteriogenesis versus angiogenesis in peripheral artery disease.
MedLine Citation:
PMID:  22271719     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Different forms of vessel growth in the adult organism contribute to the compensation for an occluded artery. We here summarize the major differences between arteriogenesis and angiogenesis and provide evidence in favour of a therapeutic stimulation of collateral growth. In addition, we outline current knowledge about regulatory mechanisms transducing the initial physical stimulus into a cellular response. As an example, the role of nitric oxide during arteriogenesis is discussed, and finally, we propose a mechanism of how an efficient decision is made that makes the larger collaterals larger and the smaller ones smaller. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Kerstin Troidl; Wolfgang Schaper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes/metabolism research and reviews     Volume:  28 Suppl 1     ISSN:  1520-7560     ISO Abbreviation:  Diabetes Metab. Res. Rev.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883450     Medline TA:  Diabetes Metab Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Division of Arteriogenesis Research, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
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