| Arteriogenesis - is this terminology necessary? | |
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MedLine Citation:
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PMID: 12494262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the collateral circulation has been controversially discussed over many decades. With the availability of purified growth factors such as the fibroblast growth factors several studies provided data, that the growth of collateral arteries, termed arteriogenesis, is not limited to its natural timecourse. When applied in experimental models FGF in particular led to a significant increase in collateral conductance upon arterial occlusion. Thus the proliferation of preexisting bypassing arterioles could be enhanced therapeutically. The purpose of this review is to discuss the physiological importance of different kinds of vascular growth (e.g. vasculogenesis, angiogenesis, arteriogenesis) to enhance blood flow to ischemic limbs or the heart. It is outlined that large conductance arteries rather than capillary networks are needed to compensate for perfusion deficits due to atherosclerotic stenosis or occlusion. |
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Authors:
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Ivo Buschmann; Eva Katzer; Christoph Bode |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Basic research in cardiology Volume: 98 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2002-12-20 Completed Date: 2003-12-12 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
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Albert Ludwigs University Freiburg Medical Clinic III, Research Group for Experimental and Clinical Arteriogenesis, Department for Cardiology and Angiology, Breisacher Str. 66, Germany. buschmann@med1.ukl.uni-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / growth & development*, physiology Collateral Circulation / physiology* Coronary Disease / physiopathology Terminology as Topic* |
| Comments/Corrections | |
Comment In:
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Basic Res Cardiol. 2003 Feb;98(1):6-7
[PMID:
12494263
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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