| Arteriogenesis, a new concept of vascular adaptation in occlusive disease. | |
| | |
MedLine Citation:
|
PMID: 12197469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The formation of collateral arteries as a process adaptive to arterial occlusion is now called 'arteriogenesis' to emphasize the difference to angiogenesis, the formation of capillaries by sprouting from pre-existent ones (W. Schaper, I. Buschmann. Cardiovasc Res 1999; 43: 835-7; I. Buschmann, W. Schaper. J Pathol 2000; 190: 338-42; D. Scholz et al. Virchows Arch 2000; 436: 257-70). The differences are that collaterals develop from pre-existing arterioles and that circulating monocytes adhere to endothelium that had been activated by the high shear stress generated by the large pressure differences between perfusion territories. Monocytes are the major producers of growth factors and of proteolytic enzymes that enable smooth muscle cells to migrate and divide. The nature of the growth factors remains uncertain. Neither FGF-1/2 nor VEGF is expressed on the transcriptional or translational level in collaterals proper and in the tissue surrounding them. Only FGF receptor 1 has a brief window of upregulation shortly after arterial occlusion. While transgenic overexpression of FGF-1 increases number and branching of arterioles, targeted disruption of FGF-1/2 does not negatively influence arteriogenesis. Cytokines that attract monocytes or prolong the life span of monocytes (MCP-1, GM CSF) are strong arteriogenic factors. Collateral vessels exhibit the same morphology whether they had formed in the heart, limbs or brain or in dogs, rabbits or mouse. They are tortuous because they also increase lengthwise in a restricted space. In animals larger than the mouse, they develop an intima, and initially, many arterioles participate in arteriogenesis, but only a few mature into large arterial channels which, when arterial occlusion had proceeded slowly enough, can replace the occluded artery to a significant proportion. Therapy with a single growth factor in animals with occluded femoral arteries significantly increases the speed of arteriogenesis but does not significantly increase the level of adaptation. It appears that the mastergene for arteriogenesis still awaits discovery. |
| | |
Authors:
|
D Scholz; W J Cai; W Schaper |
Related Documents
:
|
2180869 - Carotid thrombosis following neck irradiation. 7349009 - Biomechanics of vascular occlusion in neurosurgery. 2772209 - Transrenal ureteral occlusion with gianturco coils and gelatin sponge. 19709959 - Targeted venous occlusion using pulsed high-intensity focused ultrasound. 7502959 - Ct-defined large subcortical infarcts: correlation of location with site of cerebrovasc... 10625729 - Specific transcranial doppler flow findings related to the presence and site of arteria... 7535869 - Human transluminally placed endovascular stented grafts: preliminary histopathologic an... 16612909 - Endovenous laser treatment for primary varicose veins. 21309489 - Effect of remifentanil on arterial oxygenation during one-lung ventilation. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Angiogenesis Volume: 4 ISSN: 0969-6970 ISO Abbreviation: Angiogenesis Publication Date: 2001 |
Date Detail:
|
Created Date: 2002-08-28 Completed Date: 2002-09-18 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9814575 Medline TA: Angiogenesis Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 247-57 Citation Subset: IM |
Affiliation:
|
Kerckhoff-Clinic, Department of Cardiac Surgery, Bad Nauheim, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological* Animals Arterial Occlusive Diseases / physiopathology* Arteries / growth & development* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lamotrigine as an augmentation agent in treatment-resistant depression.
Next Document: Multiple angiogenesis stimulators in a single malignancy: implications for anti-angiogenic tumour th...