| Arteriogenesis in hypoperfused rat brain. | |
| | |
MedLine Citation:
|
PMID: 12771578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experimental and clinical studies have provided evidence for spontaneous and therapeutically induced arteriogenesis after occlusion of major peripheral or cardiac vessels. Such evidence is lacking for the cerebrovascular system. In halothane-anesthetized rats, different degrees of brain hypoperfusion were induced by one- to four-vessel occlusion, that is, one or both common carotid arteries in combination with or without bilateral vertebral artery occlusion. The flow decline was monitored by laser Doppler flowmetry, the residual hemodynamic reserve by testing flow reactivity to ventilation with 6% CO(2) and arteriogenesis by intravascular latex infusion and immunohistochemistry of vascular proliferation and monocyte adhesion. The optimum condition for induction of arteriogenesis was three-vessel (one carotid plus both vertebral arteries) occlusion, which led to reduction of blood flow to about 50% and complete suppression of CO(2) reactivity, but no histologic injury. One week after three-vessel occlusion, the ipsilateral posterior cerebral artery significantly enlarged by 39%, and after 3 weeks by 72%, paralleled by the partial return of CO(2) reactivity and the appearance of immunohistochemical markers of arteriogenesis. Three-vessel occlusion is a reliable model for the induction of arteriogenesis in the adult brain and is a new approach for exploring the potentials of arteriogenesis for the prevention of progressing brain ischemia. |
| | |
Authors:
|
Hans-Jörg Busch; Ivo R Buschmann; Günter Mies; Christoph Bode; Konstantin-Alexander Hossmann |
Related Documents
:
|
19118738 - Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual... 1446318 - Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats. 16463828 - Effect of ischemic preconditioning on brain tissue gases and ph during temporary cerebr... 1062598 - Tooth loading and cuspal guidance in canine and group-function occlusions. 10967588 - Bilateral carotid endarterectomy combined with myocardial revascularization during the ... 21149408 - Extracranial carotid artery aneurysm due to behcet's disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 23 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-05-28 Completed Date: 2003-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 621-8 Citation Subset: IM |
Affiliation:
|
Max Planck Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / blood supply Brain Ischemia / physiopathology Carbon Dioxide / blood, pharmacology Carotid Artery Diseases / physiopathology Cerebrovascular Circulation / physiology* Circle of Willis / physiology* Disease Models, Animal Infarction, Middle Cerebral Artery / physiopathology* Laser-Doppler Flowmetry Male Neovascularization, Physiologic / physiology* Rats Rats, Sprague-Dawley Stress, Mechanical Vertebrobasilar Insufficiency / physiopathology |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improved statistical power of the multilinear reference tissue approach to the quantification of neu...
Next Document: Living and dying with medical technology.