Document Detail

Arterio-venous carboxyhemoglobin difference suggests carbon monoxide production by human lungs.
MedLine Citation:
PMID:  9514911     Owner:  NLM     Status:  MEDLINE    
Carbon monoxide is hypothesized to be produced by the enzyme heme oxygenase predominantly in liver and spleen, bound to hemoglobin, and excreted by the lungs. Thus, venous carboxyhemoglobin is expected to be higher or equal to arterial carboxyhemoglobin. Unspecific inflammatory stimuli have been shown to induce heme oxygenase in lung tissue possibly leading to pulmonary carbon monoxide production. Arterial and central venous carboxyhemoglobin levels were measured in critically ill patients on the third day of ICU stay (n = 59) as well as in otherwise healthy humans prior to orthopedic surgery (n = 29). Arterial and central venous carboxyhemoglobin were higher in ICU patients than in healthy humans, respectively. In both groups, arterial carboxyhemoglobin was significantly higher than central venous carboxyhemoglobin. The arteriovenous carboxyhemoglobin differences were similar in both groups. The data suggest (a) increased CO-generation in critical illness and (b) pulmonary CO-production in healthy and critically ill humans.
J Meyer; T Prien; H Van Aken; H G Bone; R Waurick; G Theilmeier; M Booke
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  244     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-2     Citation Subset:  IM    
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfälische Wilhelms-Universität Münster, Germany.
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MeSH Terms
Arteries / metabolism*
Carbon Monoxide / blood,  metabolism*
Carboxyhemoglobin / metabolism*
Heart Atria / metabolism
Heme Oxygenase (Decyclizing) / biosynthesis
Intensive Care
Lung / enzymology,  metabolism*
Veins / metabolism*
Reg. No./Substance:
630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin; EC Oxygenase (Decyclizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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