| Arterial wall oxygen consumption rate varies spatially. | |
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MedLine Citation:
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PMID: 7149047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ratio of the O2 consumption rate (Q) to the O2 transmissibility (diffusivity-solubility product, Dk) was estimated by curve-fitting O2 tension profiles measured in vascular strips in vitro and in blood vessels in vivo. For rabbit aortic tissue in vitro, Q/Dk was 2.51 +/- 0.28 (SE) X 10(5) Torr/cm2 (n = 9). For various dog vessels in vivo, Q/Dk ranged from 0.15 to 47 X 10(5) Torr/cm2. In most cases, Q/Dk was higher near the endothelium than in the outer wall. This difference appears to be caused by a higher Q. Computer simulations using a two-layer O2 transport model with estimated Q/Dk indicate that the O2 supply from the vasa vasorum is essential to prevent medial wall hypoxia. |
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Authors:
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D G Buerk; T K Goldstick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 243 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-01-27 Completed Date: 1983-01-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H948-58 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / anatomy & histology, metabolism Arteries / anatomy & histology*, metabolism Blood Pressure Dogs Electrophysiology / methods Mathematics Models, Biological Oxygen Consumption Rabbits Swine |
| Grant Support | |
ID/Acronym/Agency:
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GM-07350/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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